SCHEMBL5110144

SCHEMBL5110144

CCCCCN1C(=O)/C(=N\NC(N)=O)c2cc(SCCCc3ccc(C(=O)O)cc3)ccc21

nearest known ligand 0.40

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
RARB P10826 8/20 0.37
MEN1 O00255 1/20 0.36
ALDH1A1 P00352 1/20 0.36
RARA P10276 1/20 0.36
MAPT P10636 1/20 0.36
MTOR P42345 1/20 0.36
KMT2A Q03164 1/20 0.36
PARK7 Q99497 1/20 0.36
PLK1 P53350 7/20 0.36
PLK3 Q9H4B4 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5110149 1.00 RARB (0.37) RARBMEN1ALDH1A1RARAMAPT
SCHEMBL14287358 1.00 RARB (0.37) RARBMEN1ALDH1A1RARAMAPT
SCHEMBL5119205 0.99 RARB (0.38) RARBMEN1ALDH1A1RARAMAPT
SCHEMBL14287353 0.99 RARB (0.38) RARBMEN1ALDH1A1RARAMAPT
SCHEMBL5126140 0.99 RARB (0.38) RARBMEN1ALDH1A1RARAMAPT
SCHEMBL5126019 0.96 PARK7 (0.39) RARBMEN1ALDH1A1RARAMAPT
SCHEMBL5118341 0.96 PARK7 (0.39) RARBMEN1ALDH1A1RARAMAPT
SCHEMBL14287343 0.96 PARK7 (0.39) RARBMEN1ALDH1A1RARAMAPT
SCHEMBL5109902 0.95 PARK7 (0.37) RARBMEN1ALDH1A1RARAMAPT
SCHEMBL14287351 0.95 PARK7 (0.37) RARBMEN1ALDH1A1RARAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080004274-A1 Novel biaromatic compounds that modulate PPAR type receptors and cosmetic/pharmaceutical compositions comprised thereof GALDERMA RESEARCH & DEVELOPMENT (FR) 2008-01-03 US claimed
US-20080004274-A1 Novel biaromatic compounds that modulate PPAR type receptors and cosmetic/pharmaceutical compositions comprised thereof GALDERMA RESEARCH & DEVELOPMENT (FR) 2008-01-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080004274-A1 Novel biaromatic compounds that modulate PPAR type receptors and cosmetic/pharmaceutical compositions comprised thereof PPARG, PPARD, PPARA RARB 37/4885MEN1 4750/4885ALDH1A1 420/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.