Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.43 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.43 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.43 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.43 |
| ▸ | AHR | P35869 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 2/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | MARS1 | P56192 | 1/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.33 |
| ▸ | CLK1 | P49759 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5108368 | 0.92 | CHRNB2 (0.43) | CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3 | |
| Hydrochloric Acid SCHEMBL5116454 | 0.91 | CHRNB2 (0.42) | CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3 | |
| SCHEMBL5121599 | 0.90 | CHRNB2 (0.46) | CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3 | |
| SCHEMBL5120541 | 0.87 | CHRNB1 (0.47) | CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3 | |
| SCHEMBL5114646 | 0.85 | CHRNB2 (0.46) | CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3 | |
| SCHEMBL5109218 | 0.84 | CHRNB4 (0.42) | CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3 | |
| SCHEMBL5123133 | 0.81 | CHRNB4 (0.39) | CHRNB2CHRNB4CHRNA3CHRNA4HTR2A | |
| SCHEMBL5111997 | 0.78 | CHRNB2 (0.54) | CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL5116116 | 0.77 | CYP11B1 (0.42) | CHRNB2CHRNB4CHRNA3CHRNA4MAPT | |
| SCHEMBL5115668 | 0.76 | CHRNB4 (0.42) | CHRNB2CHRNB4CHRNA3CHRNB1CHRNB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040106603-A1 | Diazabicyclic compounds useful in the treatment of CNS and other disorders | PFIZER INC | 2004-06-03 | — | — | US | claimed |
| US-7442694-B2 | Diazabicyclic compounds useful in the treatment of CNS and other disorders | PFIZER INC (US) | 2008-10-28 | — | — | US | disclosed |
| US-20040106603-A1 | Diazabicyclic compounds useful in the treatment of CNS and other disorders | PFIZER INC | 2004-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040106603-A1 | Diazabicyclic compounds useful in the treatment of CNS and other disorders | DBH, CHRNA6, DDT | CHRNB2 10/4885CHRNB4 11/4885CHRNA3 14/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.