Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.74 |
| ▸ | MEN1 | O00255 | 1/20 | 0.74 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.74 |
| ▸ | C5 | P01031 | 1/20 | 0.74 |
| ▸ | MAPT | P10636 | 1/20 | 0.74 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.74 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.74 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.50 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.50 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.50 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.50 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.50 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.50 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.45 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.42 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.41 |
| ▸ | TUBB | P07437 | 1/20 | 0.41 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31324198 | 1.00 | PTGS2 (0.74) | PTGS2MEN1ABCC4C5MAPT | |
| SCHEMBL31324162 | 0.93 | PTGS2 (0.64) | PTGS2MEN1ABCC4C5MAPT | |
| SCHEMBL11398303 | 0.88 | PTGS2 (0.71) | PTGS2MEN1ABCC4C5MAPT | |
| Carprofen SCHEMBL30910975 | 0.85 | PTGS2 (1.00) | PTGS2MEN1ABCC4C5MAPT | |
| Carprofen SCHEMBL3910 | 0.85 | PTGS2 (1.00) | PTGS2MEN1ABCC4C5MAPT | |
| Carprofen SCHEMBL3698103 | 0.85 | PTGS2 (1.00) | PTGS2MEN1ABCC4C5MAPT | |
| Carprofen SCHEMBL30910956 | 0.85 | PTGS2 (1.00) | PTGS2MEN1ABCC4C5MAPT | |
| Carprofen SCHEMBL3909 | 0.85 | PTGS2 (1.00) | PTGS2MEN1ABCC4C5MAPT | |
| Carprofen SCHEMBL5055325 | 0.85 | PTGS2 (1.00) | PTGS2MEN1ABCC4C5MAPT | |
| Carprofen SCHEMBL30910972 | 0.85 | PTGS2 (1.00) | PTGS2MEN1ABCC4C5MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7332516-B2 | Geminally di-substituted NSAID derivatives as Aβ42 lowering agents | MERCK + CO., INC. (US) | 2008-02-19 | — | — | US | disclosed |
| EP-1587798-A4 | GEMINALLY DI-SUBSTITUTED NSAID DERIVATIVES AS ABETA 42 LOWERING AGENTS | MERCK & CO INC (US) | 2007-06-27 | — | — | EP | disclosed |
| US-20060063937-A1 | Geminallyl di-substituted nsaid derivatives as abeta 42 lowering agents | MERCK SHARP & DOHME CORP. | 2006-03-23 | — | — | US | disclosed |
| EP-1587798-A2 | GEMINALLY DI-SUBSTITUTED NSAID DERIVATIVES AS ABETA 42 LOWERING AGENTS | Merck & Co., Inc. (US) | 2005-10-26 | — | — | EP | disclosed |
| WO-2004064771-A2 | GEMINALLY DI-SUBSTITUTED NSAID DERIVATIVES AS ABETA 42 LOWERING AGENTS | MERCK & CO., INC. (US) | 2004-08-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060063937-A1 | Geminallyl di-substituted nsaid derivatives as abeta 42 lowering agents | APP, PSEN1, CA1 | PTGS2 59/4885MEN1 1296/4885ABCC4 457/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.