Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 1/20 | 0.46 |
| ▸ | AKT1 | P31749 | 3/20 | 0.45 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.44 |
| ▸ | CTSL | P07711 | 4/20 | 0.41 |
| ▸ | CTSB | P07858 | 4/20 | 0.41 |
| ▸ | CTSS | P25774 | 3/20 | 0.41 |
| ▸ | MEP1A | Q16819 | 1/20 | 0.41 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 4/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 2/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | CTSD | P07339 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14289384 | 0.90 | PTGES (0.44) | PTGESAKT1CTSLCTSBCTSS | |
| SCHEMBL14289410 | 0.89 | GRM5 (0.45) | PTGESAKT1CTSLCTSBCTSS | |
| SCHEMBL5115199 | 0.85 | F2 (0.43) | PTGESAKT1DPP7CTSLCTSB | |
| SCHEMBL5116905 | 0.84 | DPP7 (0.49) | PTGESDPP7CTSLCTSBMEP1A | |
| SCHEMBL14289388 | 0.75 | DPP7 (0.53) | DPP7CTSLCTSBMEP1AMEP1B | |
| SCHEMBL5103191 | 0.75 | F2 (0.45) | MEP1AMEP1BF2PRSS1F10 | |
| Hydrochloric Acid SCHEMBL5107306 | 0.74 | DPP7 (0.52) | DPP7CTSLCTSBMEP1AMEP1B | |
| Hydrochloric Acid SCHEMBL5107311 | 0.74 | DPP7 (0.52) | DPP7CTSLCTSBMEP1AMEP1B | |
| SCHEMBL5115442 | 0.72 | F2 (0.73) | F2PRSS1F10 | |
| SCHEMBL5114785 | 0.72 | F2 (0.71) | F2PRSS1F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080004256-A1 | Amidinophenylalanine Derivatives as Thrombin Inhibitors | LEK PHARMACEUTICALS D.D. (SI) | 2008-01-03 | — | — | US | disclosed |
| US-20080004256-A1 | Amidinophenylalanine Derivatives as Thrombin Inhibitors | LEK PHARMACEUTICALS D.D. (SI) | 2008-01-03 | — | — | US | disclosed |
| US-20080004256-A1 | Amidinophenylalanine Derivatives as Thrombin Inhibitors | LEK PHARMACEUTICALS D.D. (SI) | 2008-01-03 | — | — | US | disclosed |
| US-7285547-B2 | Amidinophenylalanine derivatives as thrombin inhibitors | LEK PHARMACEUTICALS D.D. (SI) | 2007-10-23 | — | — | US | disclosed |
| US-7285547-B2 | Amidinophenylalanine derivatives as thrombin inhibitors | LEK PHARMACEUTICALS D.D. (SI) | 2007-10-23 | — | — | US | disclosed |
| US-7285547-B2 | Amidinophenylalanine derivatives as thrombin inhibitors | LEK PHARMACEUTICALS D.D. (SI) | 2007-10-23 | — | — | US | disclosed |
| EP-1355894-B1 | AMIDINOPHENYLALANINE DERIVATIVES AS THROMBIN INHIBITORS | UNIV LJUBLJANI (SI) | 2005-03-16 | — | — | EP | disclosed |
| US-20040048851-A1 | Amidinophenylalanine derivatives as thrombin inhibitors | UNIVERZA V LJUBLJANA (SI) | 2004-03-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040048851-A1 | Amidinophenylalanine derivatives as thrombin inhibitors | TFPI, SERPINC1, F2 | PTGES 1136/4885AKT1 2645/4885DPP7 451/4885 |
| US-20080004256-A1 | Amidinophenylalanine Derivatives as Thrombin Inhibitors | TFPI, SERPINC1, F2 | PTGES 817/4885AKT1 2460/4885DPP7 204/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.