Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CTSK | P43235 | 1/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28085774 | 0.84 | ATM (0.56) | TSHRTDP1ALDH1A1L3MBTL1CYP3A4 | |
| SCHEMBL290693 | 0.83 | MAPT (0.51) | TSHRALDH1A1L3MBTL1HCAR2HSD17B10 | |
| SCHEMBL3445677 | 0.79 | HCAR2 (0.66) | TSHRTDP1ALDH1A1L3MBTL1CYP3A4 | |
| SCHEMBL3695735 | 0.79 | ATM (0.62) | TSHRTDP1ALDH1A1L3MBTL1CYP3A4 | |
| SCHEMBL3445675 | 0.79 | HCAR2 (0.66) | TSHRTDP1ALDH1A1L3MBTL1CYP3A4 | |
| Diphenylmethane SCHEMBL28294258 | 0.78 | TSHR (0.67) | TSHRTDP1ALDH1A1L3MBTL1CYP3A4 | |
| SCHEMBL4065633 | 0.78 | HCAR2 (0.62) | TDP1ALDH1A1L3MBTL1MAPK1HCAR2 | |
| SCHEMBL7454113 | 0.77 | CTSK (0.53) | TSHRTDP1ALDH1A1L3MBTL1CYP3A4 | |
| SCHEMBL5675140 | 0.77 | TSHR (0.54) | TSHRTDP1ALDH1A1L3MBTL1CYP3A4 | |
| SCHEMBL11512655 | 0.76 | TSHR (0.52) | TSHRTDP1ALDH1A1L3MBTL1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8273740-B2 | antiallergen; not direct way to change nature of immunological response to allergen; G-protein-coupled \"chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2)\" antagonist for prostaglandin PGD2, that mediates PGD2-dependent migration of blood Th2 cells; ; asthma, rhinitis, COPD | ACTELION PHARMACEUTICALS, LTD. (CH) | 2012-09-25 | — | — | US | disclosed |
| US-20080108638-A1 | 2-Sulfanyl-Benzoimidazol-1-Yl-Acetic Acid Derivatives as Crth2 Antagonists | ACTELION PHARMACEUTICALS,LTD. (CH) | 2008-05-08 | — | — | US | disclosed |
| CN-1290871-C | styrene-based polymer resin and composition thereof | PS JAPAN CORP (JP) | 2006-12-20 | — | — | CN | disclosed |
| CN-1533402-A | styrene-based polymer resin and composition thereof | PS日本株式会社 | 2004-09-29 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080108638-A1 | 2-Sulfanyl-Benzoimidazol-1-Yl-Acetic Acid Derivatives as Crth2 Antagonists | HRH2, HRH1, HRH3 | TSHR 655/4885TDP1 4867/4885ALDH1A1 470/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.