Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 3/20 | 0.62 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.41 |
| ▸ | PHGDH | O43175 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | CBFB | Q13951 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5113058 | 0.99 | GRM5 (0.60) | GRM5NOTUMALDH1A1MEN1LMNA | |
| SCHEMBL5100815 | 0.80 | GRM5 (0.66) | GRM5TGFBR1KCNH2 | |
| Hydrochloric Acid SCHEMBL5103873 | 0.78 | GRM5 (0.64) | GRM5TGFBR1KCNH2 | |
| SCHEMBL5100415 | 0.77 | GRM5 (0.63) | GRM5NOTUMMEN1LMNAGAA | |
| SCHEMBL29979429 | 0.77 | TGFBR1 (0.60) | GRM5ALDH1A1MEN1LMNAGAA | |
| SCHEMBL4025464 | 0.77 | TGFBR1 (0.60) | GRM5ALDH1A1MEN1LMNAGAA | |
| SCHEMBL5100840 | 0.76 | GRM5 (1.00) | GRM5ALDH1A1MAPTHTT | |
| Hydrochloric Acid SCHEMBL5101454 | 0.76 | GRM5 (0.62) | GRM5NOTUMMEN1LMNAGAA | |
| SCHEMBL5078491 | 0.75 | GRM5 (0.60) | GRM5MEN1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL4033214 | 0.75 | TGFBR1 (0.59) | GRM5ALDH1A1MEN1LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7371767-B2 | Heteroaryl substituted pyrrole modulators of metabotropic glutamate receptor-5 | MERCK & CO., INC. (US) | 2008-05-13 | — | — | US | claimed |
| US-20050085514-A1 | Heteroaryl substituted pyrrole modulators of metabotropic glutamate receptor-5 | MERCK SHARP & DOHME CORP. | 2005-04-21 | — | — | US | claimed |
| EP-1458710-A4 | HETEROARYL SUBSTITUTED PYRROLE MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5 | MERCK & CO INC (US) | 2005-04-20 | — | — | EP | claimed |
| EP-1458710-A1 | HETEROARYL SUBSTITUTED PYRROLE MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5 | Merck & Co., Inc. (US) | 2004-09-22 | — | — | EP | claimed |
| WO-2004030637-A2 | TREATMENT OF OBESITY AND OTHER DISORDERS ASSOCIATED WITH EXCESSIVE FOOD INTAKE | MERCK & CO., INC. (US) | 2004-04-15 | — | — | WO | claimed |
| WO-2003059904-A1 | HETEROARYL SUBSTITUTED PYRROLE MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5 | MERCK & CO., INC. (US) | 2003-07-24 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050085514-A1 | Heteroaryl substituted pyrrole modulators of metabotropic glutamate receptor-5 | GRM5, GRIK5, GRIN2C | GRM5 1/4885NOTUM 2871/4885ALDH1A1 2777/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.