Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 2/20 | 0.59 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | HTR2A | P28223 | 3/20 | 0.52 |
| ▸ | HTR2C | P28335 | 2/20 | 0.52 |
| ▸ | FAAH | O00519 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | PARP1 | P09874 | 1/20 | 0.49 |
| ▸ | DPP4 | P27487 | 1/20 | 0.48 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.48 |
| ▸ | DRD4 | P21917 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13149912 | 0.84 | GRIN2B (0.68) | GRIN2BMEN1KMT2ATSHRGAA | |
| SCHEMBL517941 | 0.81 | PRKAA2 (0.73) | PRKAA2MEN1KMT2AFAAHKCNH2 | |
| SCHEMBL5106532 | 0.81 | PRKAA2 (0.64) | PRKAA2MEN1KMT2AHTR2AHTR2C | |
| SCHEMBL13149900 | 0.79 | GRIN2B (0.53) | GRIN2BMEN1KMT2ATSHRGAA | |
| Hydrochloric Acid SCHEMBL6584348 | 0.77 | GRIN2B (0.88) | GRIN2BPRKAA2MEN1KMT2ATSHR | |
| SCHEMBL1134958 | 0.77 | GRIN2B (0.75) | GRIN2BPRKAA2MEN1KMT2ATSHR | |
| SCHEMBL15302865 | 0.77 | PRKAA2 (0.63) | GRIN2BPRKAA2MEN1KMT2AHTR2A | |
| SCHEMBL9513154 | 0.76 | MEN1 (0.68) | PRKAA2MEN1KMT2AHTR2AHTR2C | |
| SCHEMBL2228011 | 0.76 | GAA (0.66) | MEN1KMT2ATSHRGAAMAPK1 | |
| SCHEMBL5099895 | 0.76 | HTR2A (0.55) | PRKAA2MEN1KMT2AHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7329749-B2 | Piperazinylcarbonylquinolines and -isoquinolines | MERCK PATENT GESELLSCHAFT (DE) | 2008-02-12 | — | — | US | claimed |
| WO-2002057256-A9 | PIPERAZINYLCARBONYLQUINOLINES AND -ISOQUINOLINES | MERCK PATENT GMBH (DE) | 2005-12-08 | — | — | WO | claimed |
| EP-1366039-B1 | PIPERAZINYLCARBONYLQUINOLINES AND -ISOQUINOLINES | MERCK PATENT GMBH (DE) | 2005-09-07 | — | — | EP | claimed |
| US-20040077657-A1 | Piperazinylcarbonylquinolines and -isoquinolines | MERCK PATENT GMBH (DE) | 2004-04-22 | — | — | US | claimed |
| EP-1366039-A1 | PIPERAZINYLCARBONYLQUINOLINES AND -ISOQUINOLINES | MERCK PATENT GmbH (DE) | 2003-12-03 | — | — | EP | claimed |
| WO-2002057256-A1 | PIPERAZINYLCARBONYLQUINOLINES AND -ISOQUINOLINES | MERCK PATENT GMBH (DE) | 2002-07-25 | — | — | WO | claimed |
| US-7329749-B2 | Piperazinylcarbonylquinolines and -isoquinolines | MERCK PATENT GESELLSCHAFT (DE) | 2008-02-12 | — | — | US | disclosed |
| WO-2002057256-A9 | PIPERAZINYLCARBONYLQUINOLINES AND -ISOQUINOLINES | MERCK PATENT GMBH (DE) | 2005-12-08 | — | — | WO | disclosed |
| EP-1366039-B1 | PIPERAZINYLCARBONYLQUINOLINES AND -ISOQUINOLINES | MERCK PATENT GMBH (DE) | 2005-09-07 | — | — | EP | disclosed |
| US-20040077657-A1 | Piperazinylcarbonylquinolines and -isoquinolines | MERCK PATENT GMBH (DE) | 2004-04-22 | — | — | US | disclosed |
| EP-1366039-A1 | PIPERAZINYLCARBONYLQUINOLINES AND -ISOQUINOLINES | MERCK PATENT GmbH (DE) | 2003-12-03 | — | — | EP | disclosed |
| WO-2002057256-A1 | PIPERAZINYLCARBONYLQUINOLINES AND -ISOQUINOLINES | MERCK PATENT GMBH (DE) | 2002-07-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040077657-A1 | Piperazinylcarbonylquinolines and -isoquinolines | TPH2, HTR2C, HTR1A | GRIN2B 24/4885PRKAA2 1895/4885MEN1 1677/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.