Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 4/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.66 |
| ▸ | ACP1 | P24666 | 2/20 | 0.64 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.61 |
| ▸ | GBA1 | P04062 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | ATM | Q13315 | 1/20 | 0.61 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17799974 | 0.89 | GBA1 (0.74) | PDE5AMAPK1GBA1MEN1KMT2A | |
| SCHEMBL17799893 | 0.88 | GBA1 (0.56) | PDE5AMAPK1ACP1GBA1MEN1 | |
| SCHEMBL17799977 | 0.86 | GBA1 (0.54) | PDE5AMAPK1ACP1SIRT5GBA1 | |
| SCHEMBL4860036 | 0.86 | ACP1 (0.74) | PDE5AMAPK1ACP1SIRT5GBA1 | |
| SCHEMBL5107759 | 0.85 | ACP1 (0.74) | PDE5AMAPK1ACP1GBA1MEN1 | |
| SCHEMBL17799835 | 0.83 | SLC6A3 (0.53) | PDE5AMAPK1ACP1TLR9POLB | |
| SCHEMBL12674359 | 0.83 | METAP1 (0.71) | PDE5AMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL17800023 | 0.82 | GBA1 (0.72) | PDE5AMAPK1GBA1MEN1KMT2A | |
| SCHEMBL17800020 | 0.81 | SLC6A3 (0.54) | PDE5AMAPK1GBA1TLR9POLB | |
| SCHEMBL17799984 | 0.81 | KDM1A (0.56) | PDE5AMAPK1ACP1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080207614-A1 | QUINAZOLINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF DIABETES AND OBESITY | SK CHEMICALS CO., LTD. (KR) | 2008-08-28 | — | — | US | claimed |
| US-20080207614-A1 | QUINAZOLINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF DIABETES AND OBESITY | SK CHEMICALS CO., LTD. (KR) | 2008-08-28 | — | — | US | disclosed |
| EP-1844023-A1 | QUINAZOLINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF DIABETES AND OBESITY | SK CHEMICALS CO., LTD. (KR) | 2007-10-17 | — | — | EP | disclosed |
| WO-2006071095-A1 | QUINAZOLINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF DIABETES AND OBESITY | SK CHEMICALS CO., LTD. (KR) | 2006-07-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080207614-A1 | QUINAZOLINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF DIABETES AND OBESITY | GPR119, GCKR, GLP1R | PDE5A 204/4885MAPK1 513/4885ACP1 3203/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.