Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | FSCN1 | Q16658 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TOP1 | P11387 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 2/20 | 0.35 |
| ▸ | CNR2 | P34972 | 2/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | ABHD12 | Q8N2K0 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4750105 | 0.85 | FSCN1 (0.39) | SMN1; SMN2FSCN1L3MBTL1KDM4EKMT2A | |
| SCHEMBL4750000 | 0.82 | FSCN1 (0.43) | SMN1; SMN2FSCN1KDM4ETOP1 | |
| SCHEMBL3989708 | 0.78 | SMN1; SMN2 (0.40) | SMN1; SMN2L3MBTL1POLBRECQLLMNA | |
| SCHEMBL3982263 | 0.78 | SMN1; SMN2 (0.40) | SMN1; SMN2L3MBTL1POLBRECQLLMNA | |
| SCHEMBL3982232 | 0.78 | ALDH1A1 (0.38) | SMN1; SMN2L3MBTL1KMT2APOLBRECQL | |
| SCHEMBL4746270 | 0.77 | SCD (0.40) | SMN1; SMN2FSCN1KMT2AALDH1A1HPGD | |
| SCHEMBL3981450 | 0.77 | SMN1; SMN2 (0.43) | SMN1; SMN2L3MBTL1KMT2APOLBRECQL | |
| SCHEMBL3987185 | 0.77 | SMN1; SMN2 (0.40) | SMN1; SMN2L3MBTL1POLBRECQLLMNA | |
| SCHEMBL3985459 | 0.77 | SMN1; SMN2 (0.40) | SMN1; SMN2L3MBTL1KDM4EPOLBRECQL | |
| SCHEMBL3991465 | 0.77 | ALDH1A1 (0.37) | SMN1; SMN2L3MBTL1KMT2APOLBRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7435735-B2 | Hydroxy pyridopyrrolopyrazine dione compounds useful as HIV integrase inhibitors | MERCK & CO., INC. (US) | 2008-10-14 | — | — | US | disclosed |
| US-20070093496-A1 | Hydroxy pyridopyrrolopyrazine dione compounds useful as hiv integrase inhibitors | MERCK SHARP & DOHME CORP. | 2007-04-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070093496-A1 | Hydroxy pyridopyrrolopyrazine dione compounds useful as hiv integrase inhibitors | DHPS, DPYD, TYMP | SMN1; SMN2 3773/4885FSCN1 4879/4885L3MBTL1 773/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.