Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 7/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | GPBAR1 | Q8TDU6 | 4/20 | 0.41 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
| ▸ | KMO | O15229 | 1/20 | 0.40 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5126654 | 0.89 | TDP1 (0.51) | TDP1MEN1KMT2ACYP1A2CYP2C9 | |
| SCHEMBL5126518 | 0.88 | CYP1A2 (0.56) | TDP1KMT2ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL5289303 | 0.87 | L3MBTL1 (0.45) | CYP1A2CYP2C9CYP2C19SCN9APOLB | |
| SCHEMBL5111974 | 0.84 | TDP1 (0.70) | TDP1MEN1KMT2ACYP1A2CYP2C9 | |
| SCHEMBL5125877 | 0.82 | TDP1 (0.56) | TDP1MEN1KMT2ACYP1A2CYP2C9 | |
| SCHEMBL5280054 | 0.82 | MAPT (0.41) | CYP1A2CYP2C9CYP2C19SCN9APOLB | |
| SCHEMBL5114560 | 0.81 | TDP1 (0.69) | TDP1MEN1KMT2ACYP1A2CYP2C9 | |
| SCHEMBL5111572 | 0.80 | TDP1 (0.51) | TDP1MEN1KMT2ACYP1A2CYP2C9 | |
| SCHEMBL5118225 | 0.79 | TDP1 (0.54) | TDP1MEN1KMT2ACYP1A2CYP2C9 | |
| SCHEMBL5110692 | 0.79 | TDP1 (0.54) | TDP1MEN1KMT2ACYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080194598-A1 | Pyrimidine Carboxylic Acid Derivatives and Use Thereof | BAYER HEALTHCARE AG (DE) | 2008-08-14 | — | — | US | disclosed |
| US-20080194598-A1 | Pyrimidine Carboxylic Acid Derivatives and Use Thereof | BAYER HEALTHCARE AG (DE) | 2008-08-14 | — | — | US | disclosed |
| US-20080194598-A1 | Pyrimidine Carboxylic Acid Derivatives and Use Thereof | BAYER HEALTHCARE AG (DE) | 2008-08-14 | — | — | US | disclosed |
| EP-1866289-A1 | PYRIMIDINE CARBOXYLIC ACID DERIVATIVES AND USE THEREOF | Bayer HealthCare AG (DE) | 2007-12-19 | — | — | EP | disclosed |
| WO-2006097220-A1 | PYRIMIDINE CARBOXYLIC ACID DERIVATIVES AND USE THEREOF | BAYER HEALTHCARE AG (DE) | 2006-09-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194598-A1 | Pyrimidine Carboxylic Acid Derivatives and Use Thereof | DPYD, TYMP, TYMS | TDP1 273/4885MEN1 4226/4885KMT2A 3441/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.