Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 3/20 | 0.62 |
| ▸ | HTR3A | P46098 | 2/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.45 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.45 |
| ▸ | DHFR | P00374 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 4/20 | 0.42 |
| ▸ | CNR1 | P21554 | 2/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5115976 | 0.97 | CHRNA7 (0.57) | CHRNA7HTR3ACHRNB2CHRNA4DHFR | |
| SCHEMBL6543734 | 0.95 | CHRNA7 (0.67) | CHRNA7HTR3ACHRNB2CHRNA4DHFR | |
| SCHEMBL5108483 | 0.90 | CHRNA7 (0.49) | CHRNA7HTR3ACHRNB2CHRNA4DHFR | |
| SCHEMBL5107855 | 0.87 | CHRNA7 (0.57) | CHRNA7HTR3ACHRNB2CHRNA4DHFR | |
| Hydrochloric Acid SCHEMBL5122590 | 0.86 | CHRNA7 (0.60) | CHRNA7HTR3ACHRNB2CHRNA4DHFR | |
| SCHEMBL5122228 | 0.82 | HTR3A (0.51) | CHRNA7HTR3ACHRNB2CHRNA4DHFR | |
| SCHEMBL6544013 | 0.78 | CHRNA7 (0.56) | CHRNA7HTR3ACNR2CNR1KCNH2 | |
| SCHEMBL5107874 | 0.74 | CHRNB4 (0.44) | CHRNA7HTR3ACHRNB2KCNH2 | |
| SCHEMBL6544552 | 0.74 | CHRNA7 (0.52) | CHRNA7HTR3ACHRNB2CHRNA4KCNH2 | |
| SCHEMBL5121880 | 0.73 | CHRNA7 (0.47) | CHRNA7HTR3ACHRNB2CHRNA4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551843-A1 | DIAZABICYCLIC COMPOUNDS USEFUL IN THE TREATMENT OF CNS AND OTHER DISORDERS | Pfizer Products Inc. (US) | 2005-07-13 | — | — | EP | claimed |
| US-20040106603-A1 | Diazabicyclic compounds useful in the treatment of CNS and other disorders | PFIZER INC | 2004-06-03 | — | — | US | claimed |
| WO-2004024729-A1 | DIAZABICYCLIC COMPOUNDS USEFUL IN THE TREATMENT OF CNS AND OTHER DISORDERS | PFIZER PRODUCTS INC. (US) | 2004-03-25 | — | — | WO | claimed |
| US-7442694-B2 | Diazabicyclic compounds useful in the treatment of CNS and other disorders | PFIZER INC (US) | 2008-10-28 | — | — | US | disclosed |
| US-7318964-B2 | Fluorene compounds containing various functional groups, polymers thereof and EL element using the same | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2008-01-15 | — | — | US | disclosed |
| EP-1551843-A1 | DIAZABICYCLIC COMPOUNDS USEFUL IN THE TREATMENT OF CNS AND OTHER DISORDERS | Pfizer Products Inc. (US) | 2005-07-13 | — | — | EP | disclosed |
| US-20040106603-A1 | Diazabicyclic compounds useful in the treatment of CNS and other disorders | PFIZER INC | 2004-06-03 | — | — | US | disclosed |
| WO-2004024729-A1 | DIAZABICYCLIC COMPOUNDS USEFUL IN THE TREATMENT OF CNS AND OTHER DISORDERS | PFIZER PRODUCTS INC. (US) | 2004-03-25 | — | — | WO | disclosed |
| US-20030091859-A1 | Fluorene compounds containing various functional groups, polymers thereof and el element using the same | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2003-05-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030091859-A1 | Fluorene compounds containing various functional groups, polymers thereof and el element using the same | AFF4, AFF2, LEF1 | CHRNA7 4433/4885HTR3A 4568/4885CHRNB2 4123/4885 |
| US-20040106603-A1 | Diazabicyclic compounds useful in the treatment of CNS and other disorders | DBH, CHRNA6, DDT | CHRNA7 13/4885HTR3A 314/4885CHRNB2 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.