Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 11/20 | 0.45 |
| ▸ | BCDIN3D | Q7Z5W3 | 2/20 | 0.42 |
| ▸ | PDE6D | O43924 | 1/20 | 0.40 |
| ▸ | PDE6A | P16499 | 1/20 | 0.40 |
| ▸ | PDE6G | P18545 | 1/20 | 0.40 |
| ▸ | PDE6B | P35913 | 1/20 | 0.40 |
| ▸ | PDE6C | P51160 | 1/20 | 0.40 |
| ▸ | PDE6H | Q13956 | 1/20 | 0.40 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.40 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.39 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.39 |
| ▸ | PGK1 | P00558 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5123250 | 0.92 | MEN1 (0.43) | PDE5A | |
| SCHEMBL5124090 | 0.90 | USP1 (0.46) | LIMK1LIMK2 | |
| SCHEMBL5129625 | 0.89 | PDE5A (0.45) | PDE5ABCDIN3D | |
| SCHEMBL5114999 | 0.89 | PRKCI (0.43) | PDE5ABCDIN3DLIMK1LIMK2PGK1 | |
| SCHEMBL5128040 | 0.89 | PDE5A (0.43) | PDE5ABCDIN3DLIMK1LIMK2 | |
| SCHEMBL5117610 | 0.88 | PDE5A (0.42) | PDE5ABCDIN3DLIMK1LIMK2 | |
| SCHEMBL5120310 | 0.87 | MAPT (0.47) | PDE5ABCDIN3DPGK1 | |
| SCHEMBL5122271 | 0.86 | PDE5A (0.47) | PDE5ABCDIN3DPDE6DPDE6APDE6G | |
| SCHEMBL7508291 | 0.86 | BCDIN3D (0.42) | PDE5ABCDIN3D | |
| SCHEMBL7522772 | 0.85 | BCDIN3D (0.42) | PDE5ABCDIN3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080045529-A1 | Use Of Thienopyrimidines | MERCK PATENT GMBH (DE) | 2008-02-21 | — | — | US | disclosed |
| EP-1685136-A1 | USE OF THIENOPYRIMIDINES | MERCK PATENT GmbH (DE) | 2006-08-02 | — | — | EP | disclosed |
| WO-2005047292-A1 | USE OF THIENOPYRIMIDINES | MERCK PATENT GMBH (DE) | 2005-05-26 | — | — | WO | disclosed |
| US-6110920-A | TREATMENT OF CARDIOVASCULAR DISORDERS AND IMPOTENCY | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-08-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080045529-A1 | Use Of Thienopyrimidines | TIE1, DPYD, TK2 | PDE5A 2002/4885BCDIN3D 1161/4885PDE6D 2877/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.