Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.45 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.45 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5107050 | 0.93 | SMN1; SMN2 (0.55) | SMN1; SMN2L3MBTL1ALDH1A1HTTUSP2 | |
| SCHEMBL5119766 | 0.88 | CREBBP (0.62) | SMN1; SMN2L3MBTL1ALDH1A1HTTMAPT | |
| SCHEMBL5116144 | 0.87 | SMN1; SMN2 (0.49) | SMN1; SMN2L3MBTL1ALDH1A1HTTPOLB | |
| SCHEMBL9662476 | 0.82 | SMN1; SMN2 (0.59) | SMN1; SMN2L3MBTL1ALDH1A1HTTUSP2 | |
| SCHEMBL9526406 | 0.81 | SMN1; SMN2 (0.60) | SMN1; SMN2L3MBTL1ALDH1A1HTTUSP2 | |
| SCHEMBL1557718 | 0.81 | ALDH1A1 (0.67) | L3MBTL1ALDH1A1HTTPOLBMAPT | |
| SCHEMBL8123048 | 0.80 | SMN1; SMN2 (0.60) | SMN1; SMN2L3MBTL1ALDH1A1HTTUSP2 | |
| SCHEMBL11284780 | 0.80 | AKT1 (0.50) | L3MBTL1ALDH1A1POLBMAPTCREBBP | |
| SCHEMBL14667298 | 0.79 | SMN1; SMN2 (0.56) | SMN1; SMN2L3MBTL1ALDH1A1HTTUSP2 | |
| SCHEMBL7164453 | 0.79 | HDAC1 (0.55) | SMN1; SMN2L3MBTL1ALDH1A1HTTUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8273740-B2 | antiallergen; not direct way to change nature of immunological response to allergen; G-protein-coupled \"chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2)\" antagonist for prostaglandin PGD2, that mediates PGD2-dependent migration of blood Th2 cells; ; asthma, rhinitis, COPD | ACTELION PHARMACEUTICALS, LTD. (CH) | 2012-09-25 | — | — | US | disclosed |
| US-20080108638-A1 | 2-Sulfanyl-Benzoimidazol-1-Yl-Acetic Acid Derivatives as Crth2 Antagonists | ACTELION PHARMACEUTICALS,LTD. (CH) | 2008-05-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080108638-A1 | 2-Sulfanyl-Benzoimidazol-1-Yl-Acetic Acid Derivatives as Crth2 Antagonists | HRH2, HRH1, HRH3 | SMN1; SMN2 3386/4885L3MBTL1 4614/4885ALDH1A1 470/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.