Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 5/20 | 0.46 |
| ▸ | PPARA | Q07869 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | PPARD | Q03181 | 1/20 | 0.45 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.36 |
| ▸ | ADCY1 | Q08828 | 4/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | ADCY8 | P40145 | 1/20 | 0.34 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10810604 | 1.00 | PPARG (0.46) | PPARGPPARAKDM4EPPARDS1PR1 | |
| SCHEMBL10807845 | 0.98 | KDM4E (0.47) | PPARGPPARAKDM4EPPARDS1PR1 | |
| SCHEMBL15637053 | 0.92 | KDM4E (0.49) | PPARGPPARAKDM4EPPARDHPGD | |
| SCHEMBL10813251 | 0.82 | ADCY1 (0.38) | PPARGPPARAPPARDS1PR1S1PR5 | |
| SCHEMBL9097721 | 0.81 | PPARG (0.42) | PPARGPPARAPPARDADCY1CYP2C19 | |
| SCHEMBL10812386 | 0.80 | PPARG (0.37) | PPARGPPARAPPARDS1PR1ADCY1 | |
| SCHEMBL10808564 | 0.79 | KDM4E (0.44) | PPARGPPARAKDM4EPPARDNPSR1 | |
| SCHEMBL10810549 | 0.79 | PPARG (0.40) | PPARGPPARAPPARDADCY1CYP2C19 | |
| SCHEMBL4484815 | 0.78 | PPARG (0.45) | PPARGPPARAPPARDADCY1CYP2C19 | |
| SCHEMBL5124410 | 0.78 | PPARG (0.51) | PPARGPPARAKDM4EPPARDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0096890-B1 | OXAZOLEACETIC ACID DERIVATIVES, PROCESS FOR THEIR PRODUCTION AND COMPOSITIONS CONTAINING SAID DERIVATIVES | Takeda Chemical Industries, Ltd. (JP) | 1987-11-25 | — | — | EP | claimed |
| US-4602027-A | HYPOGLYCEMIC AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1986-07-22 | — | — | US | claimed |
| EP-0096890-A2 | Oxazoleacetic acid derivatives, process for their production and compositions containing said derivatives | Takeda Chemical Industries, Ltd. (JP) | 1983-12-28 | — | — | EP | claimed |
| CN-1711084-B | Substituted 4-alkoxyoxazol derivatives as PPAR agonists | HOFFMANN LA ROCHE | 2010-04-28 | — | — | CN | disclosed |
| US-7345070-B2 | Side effects reduction; Diabetes mellitus, Syndrome X, Type II diabetes, hyperglycemia, hyperlipidemia, obesity, coagaulopathy, hypertension, atherosclerosis; 3-{4-[2-(2-phenyl-5-methyl-oxazol-4-yl)-ethoxy]-phenyl}-2-methyl-2-phenoxy-propionic acid | ELI LILLY AND COMPANY (US) | 2008-03-18 | — | — | US | disclosed |
| EP-1572203-B1 | SUBSTITUTED 4-ALKOXYOXAZOL DERIVATIVES AS PPAR AGONISTS | HOFFMANN LA ROCHE (CH) | 2007-11-07 | — | — | EP | disclosed |
| EP-1313716-B1 | OXAZOLYL-ARYLPROPIONIC ACID DERIVATIVES AND THEIR USE AS PPAR AGONISTS | LILLY CO ELI (US) | 2007-05-02 | — | — | EP | disclosed |
| US-7109225-B2 | Antidiabetic agents; hypotensive agents; anticholesterol agents; antilipemic agents; antiinflammatory agents; antiproliferative agents | HOFMANN-LA ROCHE INC. (US) | 2006-09-19 | — | — | US | disclosed |
| CN-1711084-A | Substituted 4-alkoxyoxazol derivatives as PPAR agonists | HOFFMANN LA ROCHE (CH) | 2005-12-21 | — | — | CN | disclosed |
| US-20050245584-A1 | Peroxisome proliferator activated receptor agonists | BROOKS DAWN A | 2005-11-03 | — | — | US | disclosed |
| EP-1572203-A1 | SUBSTITUTED 4-ALKOXYOXAZOL DERIVATIVES AS PPAR AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-09-14 | — | — | EP | disclosed |
| WO-2002016331-A1 | OXAZOLYL-ARYLPROPIONIC ACID DERIVATIVES AND THEIR USE AS PPAR AGONISTS | ELI LILLY AND COMPANY (US) | 2002-02-28 | — | — | WO | disclosed |
| US-5498621-A | Oxazolidinedione hypoglycemic agents | PFIZER INC. (US) | 1996-03-12 | — | — | US | disclosed |
| EP-0428312-B1 | Oxazolidinedione hypoglycemic agents | PFIZER (US) | 1994-12-28 | — | — | EP | disclosed |
| WO-1991007107-A1 | OXAZOLIDINEDIONE HYPOGLYCEMIC AGENTS | PFIZER INC. (US) | 1991-05-30 | — | — | WO | disclosed |
| EP-0428312-A2 | Oxazolidinedione hypoglycemic agents | PFIZER INC. (US) | 1991-05-22 | — | — | EP | disclosed |
| EP-0096890-B1 | OXAZOLEACETIC ACID DERIVATIVES, PROCESS FOR THEIR PRODUCTION AND COMPOSITIONS CONTAINING SAID DERIVATIVES | Takeda Chemical Industries, Ltd. (JP) | 1987-11-25 | — | — | EP | disclosed |
| EP-0124384-B1 | DERIVATIVES OF ORTHOCONDENSED PYRROLE USEFUL FOR THE PREPARATION OF MEDICINES AND THEIR PREPARATION | RHONE-POULENC SANTE (FR) | 1987-08-05 | — | — | EP | disclosed |
| US-4602027-A | HYPOGLYCEMIC AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1986-07-22 | — | — | US | disclosed |
| EP-0096890-A2 | Oxazoleacetic acid derivatives, process for their production and compositions containing said derivatives | Takeda Chemical Industries, Ltd. (JP) | 1983-12-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050245584-A1 | Peroxisome proliferator activated receptor agonists | PPARG, PPARA, PPARD | PPARG 1/4885PPARA 2/4885KDM4E 3194/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.