Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCKBR | P32239 | 2/20 | 0.74 |
| ▸ | PDE5A | O76074 | 5/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.68 |
| ▸ | TSHR | P16473 | 2/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.68 |
| ▸ | HTT | P42858 | 1/20 | 0.68 |
| ▸ | MEN1 | O00255 | 3/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17760639 | 0.93 | PDE5A (0.71) | CCKBRPDE5AKDM4ETSHRHSD17B10 | |
| SCHEMBL1922143 | 0.93 | PDE5A (0.71) | CCKBRPDE5AKDM4ETSHRHSD17B10 | |
| SCHEMBL1921747 | 0.91 | CCKBR (0.82) | CCKBRPDE5AKDM4ETSHRHSD17B10 | |
| SCHEMBL12967653 | 0.91 | CCKBR (0.82) | CCKBRPDE5AKDM4ETSHRHSD17B10 | |
| SCHEMBL1922130 | 0.91 | CCKBR (0.82) | CCKBRPDE5AKDM4ETSHRHSD17B10 | |
| SCHEMBL12967991 | 0.91 | CCKBR (0.82) | CCKBRPDE5AKDM4ETSHRHSD17B10 | |
| SCHEMBL16489369 | 0.91 | CCKBR (0.82) | CCKBRPDE5AKDM4ETSHRHSD17B10 | |
| SCHEMBL5183457 | 0.89 | CCKBR (0.68) | CCKBRPDE5AKDM4ETSHRHSD17B10 | |
| SCHEMBL1921528 | 0.89 | CCKBR (0.85) | CCKBRPDE5AKDM4ETSHRHSD17B10 | |
| SCHEMBL13402875 | 0.89 | CCKBR (0.85) | CCKBRPDE5AKDM4ETSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080125452-A1 | Indolopyridines,Benzofuranopyridines and Benzothienopyridines | ALTANA PHARMA AG (DE) | 2008-05-29 | — | — | US | disclosed |
| EP-1856117-A1 | INDOLOPYRIDINES, BENZOFURANOPYRIDINES AND BENZOTHIENOPYRIDINES | Nycomed GmbH (DE) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006079644-A1 | INDOLOPYRIDINES, BENZOFURANOPYRIDINES AND BENZOTHIENOPYRIDINES | NYCOMED GMBH (DE) | 2006-08-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080125452-A1 | Indolopyridines,Benzofuranopyridines and Benzothienopyridines | BAX, AIFM1, API5 | CCKBR 2283/4885PDE5A 2394/4885KDM4E 2850/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.