Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 14/20 | 0.68 |
| ▸ | GRK2 | P25098 | 13/20 | 0.68 |
| ▸ | PRKCA | P17252 | 6/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | PRKACA | P17612 | 1/20 | 0.53 |
| ▸ | GSK3A | P49840 | 1/20 | 0.53 |
| ▸ | GSK3B | P49841 | 1/20 | 0.53 |
| ▸ | PRKX | P51817 | 1/20 | 0.53 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.53 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.53 |
| ▸ | GRK3 | P35626 | 2/20 | 0.53 |
| ▸ | GRK5 | P34947 | 1/20 | 0.53 |
| ▸ | GRK7 | Q8WTQ7 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4788257 | 0.89 | ROCK2 (0.56) | ROCK2GRK2PRKCACYP3A4CYP2D6 | |
| SCHEMBL5122272 | 0.87 | ROCK2 (0.76) | ROCK2GRK2PRKCACYP3A4CYP2D6 | |
| SCHEMBL4790264 | 0.86 | ROCK2 (0.53) | ROCK2GRK2PRKCACYP3A4GRK3 | |
| SCHEMBL4790124 | 0.85 | ROCK2 (0.59) | ROCK2GRK2PRKCAPRKACAGSK3A | |
| SCHEMBL5112465 | 0.85 | ROCK2 (0.56) | ROCK2GRK2PRKCAPRKACAGSK3A | |
| SCHEMBL5116756 | 0.85 | ROCK2 (0.59) | ROCK2GRK2PRKCACYP3A4CYP2D6 | |
| SCHEMBL5117843 | 0.84 | ROCK2 (0.61) | ROCK2GRK2PRKCAROCK1GRK3 | |
| SCHEMBL5123857 | 0.83 | ROCK2 (0.57) | ROCK2GRK2PRKCAPRKACAGSK3A | |
| SCHEMBL4789976 | 0.81 | ROCK2 (0.60) | ROCK2GRK2PRKCACYP3A4CYP2D6 | |
| SCHEMBL5117901 | 0.81 | ALDH1A1 (0.54) | ROCK2GRK2PRKCAGRK3GRK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008011557-A2 | HETEROARYL INHIBITORS OF RHO KINASE | BORCHARDT ALLEN J (US) | 2008-01-24 | — | — | WO | disclosed |
| US-20080021217-A1 | HETEROCYCLIC INHIBITORS OF RHO KINASE | Borchardt, Allen (US) | 2008-01-24 | — | — | US | disclosed |
| US-20080021217-A1 | HETEROCYCLIC INHIBITORS OF RHO KINASE | Borchardt, Allen (US) | 2008-01-24 | — | — | US | disclosed |
| US-20080021217-A1 | HETEROCYCLIC INHIBITORS OF RHO KINASE | Borchardt, Allen (US) | 2008-01-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080021217-A1 | HETEROCYCLIC INHIBITORS OF RHO KINASE | ROCK1, ROCK2, RHOA | ROCK2 2/4885GRK2 254/4885PRKCA 110/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.