Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 8/20 | 0.69 |
| ▸ | MEN1 | O00255 | 7/20 | 0.69 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14099386 | 0.90 | KMT2A (0.63) | KMT2AMEN1TDP1CYP1A2CYP2C9 | |
| SCHEMBL5126068 | 0.85 | KMT2A (0.71) | KMT2AMEN1TDP1CYP1A2CYP2C9 | |
| SCHEMBL5126454 | 0.84 | KMT2A (0.69) | KMT2AMEN1TDP1CYP1A2CYP2C9 | |
| SCHEMBL5111594 | 0.84 | KMT2A (0.69) | KMT2AMEN1TDP1CYP1A2CYP2C9 | |
| SCHEMBL5117637 | 0.83 | TDP1 (0.60) | KMT2AMEN1TDP1CYP1A2CYP2C9 | |
| SCHEMBL5127183 | 0.82 | KMT2A (0.67) | KMT2AMEN1TDP1CYP1A2CYP2C9 | |
| SCHEMBL5115261 | 0.82 | MEN1 (1.00) | KMT2AMEN1TDP1CYP1A2CYP2C9 | |
| SCHEMBL5124890 | 0.81 | KMT2A (0.64) | KMT2AMEN1TDP1CYP1A2CYP2C9 | |
| SCHEMBL5119125 | 0.81 | TDP1 (0.65) | KMT2AMEN1TDP1CYP1A2CYP2C9 | |
| SCHEMBL29050110 | 0.80 | KMT2A (0.71) | KMT2AMEN1TDP1CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080194598-A1 | Pyrimidine Carboxylic Acid Derivatives and Use Thereof | BAYER HEALTHCARE AG (DE) | 2008-08-14 | — | — | US | disclosed |
| US-20080194598-A1 | Pyrimidine Carboxylic Acid Derivatives and Use Thereof | BAYER HEALTHCARE AG (DE) | 2008-08-14 | — | — | US | disclosed |
| US-20080194598-A1 | Pyrimidine Carboxylic Acid Derivatives and Use Thereof | BAYER HEALTHCARE AG (DE) | 2008-08-14 | — | — | US | disclosed |
| CN-101175731-A | Pyrimidine carboxylic acid derivatives and uses thereof | BAYER HEALTHCARE AG (DE) | 2008-05-07 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194598-A1 | Pyrimidine Carboxylic Acid Derivatives and Use Thereof | DPYD, TYMP, TYMS | KMT2A 3441/4885MEN1 4226/4885TDP1 273/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.