Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | SLC7A5 | Q01650 | 4/20 | 0.45 |
| ▸ | PLAU | P00749 | 1/20 | 0.44 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.43 |
| ▸ | F10 | P00742 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7979206 | 0.81 | RAB9A (0.55) | NPC1RAB9AHPGDSMN1; SMN2PLAU | |
| SCHEMBL7979207 | 0.77 | GPR84 (0.51) | NPC1RAB9AHPGDSMN1; SMN2PLAU | |
| SCHEMBL5111209 | 0.77 | TSHR (0.46) | RAB9AHPGDPAX8MEN1KMT2A | |
| SCHEMBL7965774 | 0.74 | NPC1 (0.49) | NPC1RAB9AHPGDSMN1; SMN2PLAU | |
| SCHEMBL8075519 | 0.73 | NPC1 (0.49) | NPC1RAB9AHPGDSMN1; SMN2PLAU | |
| SCHEMBL2237828 | 0.72 | EPHX2 (0.57) | NPC1RAB9ASMN1; SMN2KMT2ATDP1 | |
| SCHEMBL2237833 | 0.72 | EPHX2 (0.57) | NPC1RAB9ASMN1; SMN2KMT2ATDP1 | |
| SCHEMBL17892361 | 0.72 | SLC7A5 (0.53) | SLC7A5MEN1ALOX15CYP2C19KMT2A | |
| SCHEMBL17892364 | 0.72 | SLC7A5 (0.53) | SLC7A5MEN1ALOX15CYP2C19KMT2A | |
| SCHEMBL25361142 | 0.72 | SLC7A5 (0.66) | NPC1RAB9ASMN1; SMN2SLC7A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1481965-B1 | AROMATIC AMINO ACID DERIVATIVES AND MEDICINAL COMPOSITIONS | ENDO HITOSHI (JP) | 2015-07-29 | — | — | EP | disclosed |
| US-7345068-B2 | Aromatic amino acid derivatives and medicinal compositions | Endou, Hitoshi (JP) | 2008-03-18 | — | — | US | disclosed |
| US-20050119256-A1 | Aromatic amino acid derivates and medicinal compositions | HITOSHI ENDOU (JP) | 2005-06-02 | — | — | US | disclosed |
| EP-1481965-A1 | AROMATIC AMINO ACID DERIVATIVES AND MEDICINAL COMPOSITIONS | Endo, Hitoshi (JP) | 2004-12-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050119256-A1 | Aromatic amino acid derivates and medicinal compositions | SLC7A1, SLC1A5, SLC7A5 | NPC1 602/4885RAB9A 1260/4885HPGD 1726/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.