SCHEMBL5126476

SCHEMBL5126476

CCC(C)C(CN)NS(=O)(=O)c1cccc2c(Cl)nccc12

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5AP P20292 1/20 0.38
FEN1 P39748 1/20 0.38
CYP3A4 P08684 8/20 0.38
CYP1A2 P05177 6/20 0.38
CYP2C19 P33261 5/20 0.38
CYP2D6 P10635 5/20 0.38
CYP2C9 P11712 4/20 0.38
FPR2 P25090 2/20 0.38
KDM4E B2RXH2 1/20 0.38
MTOR P42345 1/20 0.38
CSNK1A1 P48729 1/20 0.38
MYLK Q15746 1/20 0.38
HSD17B10 Q99714 1/20 0.38
TP53 P04637 7/20 0.37
THPO P40225 4/20 0.37
PMP22 Q01453 3/20 0.37
NPSR1 Q6W5P4 3/20 0.37
NFKB1 P19838 3/20 0.37
CA1 P00915 1/20 0.37
CA2 P00918 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2905215 0.85 EDNRA (0.41) ALOX5APFEN1CYP3A4CYP1A2CYP2C19
SCHEMBL9831271 0.79 CYP3A4 (0.41) CYP3A4CYP1A2CYP2C19CYP2D6CYP2C9
SCHEMBL8673967 0.78 CYP3A4 (0.37) CYP3A4CYP1A2CYP2C19CYP2D6CYP2C9
SCHEMBL2907912 0.76 CYP3A4 (0.42) ALOX5APFEN1CYP3A4CYP1A2CYP2C19
SCHEMBL5128445 0.75 CYP3A4 (0.44) ALOX5APFEN1CYP3A4CYP1A2CYP2C19
SCHEMBL2910152 0.74 EDNRA (0.39) ALOX5APFEN1CYP3A4CYP1A2CYP2C19
SCHEMBL9833038 0.74 CYP3A4 (0.42) ALOX5APFEN1CYP3A4CYP1A2CYP2C19
SCHEMBL2909360 0.73 CYP3A4 (0.68) CYP3A4CYP1A2CYP2C19CYP2D6CYP2C9
SCHEMBL2901728 0.72 SLC6A9 (0.39) CYP3A4CYP1A2CYP2C19CYP2D6CYP2C9
SCHEMBL10019204 0.71 LMNA (0.42) ALOX5APFEN1CYP3A4PMP22APEX1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008049000-A2 COMBINATION THERAPY FOR PULMONARY ARTERIAL HYPERTENSION UNITED THERAPEUTICS CORPORATION (US) 2008-04-24 WO disclosed