Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.67 |
| ▸ | MEN1 | O00255 | 2/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.65 |
| ▸ | NPC1 | O15118 | 2/20 | 0.65 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.59 |
| ▸ | GPR183 | P32249 | 1/20 | 0.59 |
| ▸ | PARP1 | P09874 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.57 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7893969 | 0.87 | KMT2A (0.85) | KMT2AMEN1MAPK1NPC1PDE4B | |
| SCHEMBL3055130 | 0.83 | PDE4B (0.66) | KMT2AMEN1MAPK1NPC1PDE4B | |
| SCHEMBL5125288 | 0.83 | KMT2A (0.68) | KMT2AMEN1MAPK1NPC1PDE4B | |
| SCHEMBL16089692 | 0.82 | MAPK1 (0.73) | KMT2AMEN1MAPK1NPC1PDE4B | |
| SCHEMBL9416605 | 0.82 | LMNA (0.75) | KMT2AMEN1MAPK1NPC1PDE4B | |
| SCHEMBL30914579 | 0.81 | MAPK1 (0.71) | KMT2AMEN1MAPK1NPC1PDE4B | |
| SCHEMBL30267843 | 0.81 | PDE4B (0.80) | KMT2AMEN1MAPK1NPC1PDE4B | |
| SCHEMBL7894613 | 0.81 | PDE4B (0.80) | KMT2AMEN1MAPK1NPC1PDE4B | |
| SCHEMBL30267796 | 0.81 | PDE4B (0.80) | KMT2AMEN1MAPK1NPC1PDE4B | |
| SCHEMBL7894615 | 0.81 | MAPK1 (0.71) | KMT2AMEN1MAPK1NPC1PDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080161344-A1 | Melanin Concentrating Hormone Receptor Ligands: Substituted Tetrahydroisoquinoline Analogues | NEUROGEN CORPORATION | 2008-07-03 | — | — | US | claimed |
| WO-2005077903-A2 | MELANIN CONCENTRATING HORMONE RECEPTOR LIGANDS: SUBSTITUTED TETRAHYDROISOQUINOLINE ANALOGUES | NEUROGEN CORPORATION (US) | 2005-08-25 | — | — | WO | claimed |
| US-20080161344-A1 | Melanin Concentrating Hormone Receptor Ligands: Substituted Tetrahydroisoquinoline Analogues | NEUROGEN CORPORATION | 2008-07-03 | — | — | US | disclosed |
| US-20080161344-A1 | Melanin Concentrating Hormone Receptor Ligands: Substituted Tetrahydroisoquinoline Analogues | NEUROGEN CORPORATION | 2008-07-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080161344-A1 | Melanin Concentrating Hormone Receptor Ligands: Substituted Tetrahydroisoquinoline Analogues | MCHR1, MCHR2, MC1R | KMT2A 1121/4885MEN1 643/4885MAPK1 3485/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.