Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 9/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | EED | O75530 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL513437 | 0.84 | GRM5 (0.57) | GRM5CYP3A4MAPTALDH1A1MAPK1 | |
| SCHEMBL513081 | 0.82 | GRM5 (0.45) | GRM5CYP3A4MAPTALDH1A1MAPK1 | |
| SCHEMBL513354 | 0.80 | GRM5 (0.47) | GRM5CYP3A4MAPTALDH1A1MAPK1 | |
| SCHEMBL512736 | 0.78 | GRM5 (0.45) | GRM5CYP3A4MAPTALDH1A1MAPK1 | |
| SCHEMBL512878 | 0.77 | GRM5 (0.44) | GRM5CYP3A4MAPTALDH1A1MAPK1 | |
| SCHEMBL512661 | 0.77 | GRM5 (0.47) | GRM5CYP3A4MAPTALDH1A1MAPK1 | |
| SCHEMBL512328 | 0.76 | GRM5 (0.48) | GRM5CYP3A4MAPTALDH1A1MAPK1 | |
| SCHEMBL513331 | 0.76 | GRM5 (0.47) | GRM5CYP3A4MAPTALDH1A1MAPK1 | |
| SCHEMBL3720958 | 0.75 | GRM5 (0.49) | GRM5CYP3A4MAPTALDH1A1MAPK1 | |
| SCHEMBL3775736 | 0.75 | GRM5 (0.49) | GRM5CYP3A4MAPTALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120028931-A1 | HETEROCYCLIC M-GLU5 ANTAGONISTS | RECORDATI IRELAND LIMITED (IE) | 2012-02-02 | — | — | US | claimed |
| US-20120028931-A1 | HETEROCYCLIC M-GLU5 ANTAGONISTS | RECORDATI IRELAND LIMITED (IE) | 2012-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028931-A1 | HETEROCYCLIC M-GLU5 ANTAGONISTS | OPRM1, GRM5, OPRD1 | GRM5 2/4885CYP3A4 1085/4885P2RX7 455/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.