Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK1 | P51617 | 1/20 | 0.49 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.42 |
| ▸ | CAMKK1 | Q8N5S9 | 1/20 | 0.40 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3334180 | 0.88 | MAP4K4 (0.52) | LMNAMAP4K4DHODHKDRRAF1 | |
| SCHEMBL3336126 | 0.88 | MAP4K4 (0.52) | IRAK4PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL5131672 | 0.83 | RAB9A (0.49) | IRAK1IRAK4PIK3CDPIK3CAPIK3CB | |
| SCHEMBL3336037 | 0.74 | MAP4K4 (0.52) | IRAK4LMNAPIK3CDPIK3CAPIK3CB | |
| SCHEMBL3335725 | 0.72 | MAP4K4 (0.41) | PIK3CAMAP4K4SCN9A | |
| SCHEMBL3334604 | 0.72 | ADORA2A (0.50) | LMNAMAP4K4DHODHSCN9ACYP1A2 | |
| SCHEMBL3336424 | 0.71 | PIK3CD (0.53) | IRAK1IRAK4LMNAPIK3CDPIK3CA | |
| SCHEMBL3332824 | 0.71 | PIK3CD (0.74) | IRAK1IRAK4PIK3CDPIK3CAPIK3CB | |
| SCHEMBL3334866 | 0.71 | MAP4K4 (0.57) | LMNAMAP4K4RAF1BRAFUSP2 | |
| SCHEMBL3333219 | 0.69 | PIK3CD (0.51) | IRAK4LMNAPIK3CDPIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008009077-A2 | 4,6-DL- AND 2,4,6-TRISUBSTITUTED QUINAZOLINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS USEFUL FOR TREATING VIRAL INFECTIONS | GILEAD SCIENCES, INC. (US) | 2008-01-24 | — | — | WO | claimed |