Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.46 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | RAF1 | P04049 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.42 |
| ▸ | FDPS | P14324 | 1/20 | 0.42 |
| ▸ | ACACB | O00763 | 1/20 | 0.42 |
| ▸ | PPIA | P62937 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAP3K8 | P41279 | 1/20 | 0.41 |
| ▸ | CAMKK1 | Q8N5S9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3333219 | 0.90 | PIK3CD (0.51) | RAB9AIRAK4PIK3CDPIK3CAPIK3CB | |
| SCHEMBL3335286 | 0.90 | RAB9A (0.56) | RAB9ACYP11B1CYP11B2JAK2RAF1 | |
| SCHEMBL5127768 | 0.83 | IRAK1 (0.49) | IRAK1IRAK4PIK3CDPIK3CAPIK3CB | |
| SCHEMBL3337576 | 0.78 | RAB9A (0.51) | RAB9APIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL3334949 | 0.77 | BRAF (0.43) | RAB9ABRAFKDM4EMEN1KMT2A | |
| SCHEMBL3340079 | 0.77 | JAK2 (0.47) | CYP11B1CYP11B2PIK3CAJAK2BRAF | |
| SCHEMBL5127968 | 0.77 | CNR1 (0.35) | CYP11B1CYP11B2JAK2ACACBPPIA | |
| SCHEMBL3338478 | 0.77 | RAB9A (0.56) | RAB9ARAF1BRAFMAP4K4MAP3K8 | |
| SCHEMBL3341282 | 0.77 | GHSR (0.54) | CYP11B1CYP11B2JAK2MAP4K4FDPS | |
| SCHEMBL3337132 | 0.77 | CYP2D6 (0.42) | RAB9AMAP4K4KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008009077-A2 | 4,6-DL- AND 2,4,6-TRISUBSTITUTED QUINAZOLINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS USEFUL FOR TREATING VIRAL INFECTIONS | GILEAD SCIENCES, INC. (US) | 2008-01-24 | — | — | WO | claimed |
| WO-2008009077-A2 | 4,6-DL- AND 2,4,6-TRISUBSTITUTED QUINAZOLINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS USEFUL FOR TREATING VIRAL INFECTIONS | GILEAD SCIENCES, INC. (US) | 2008-01-24 | — | — | WO | disclosed |