Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 3/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4836547 | 0.89 | ALDH1A1 (0.43) | ABCB1HSD17B10ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL4826532 | 0.89 | ALDH1A1 (0.43) | ABCB1HSD17B10ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL4831175 | 0.82 | ALDH1A1 (0.41) | HSD17B10ALDH1A1SMN1; SMN2NPSR1MAPT | |
| SCHEMBL4833641 | 0.81 | ALDH1A1 (0.49) | LMNAHSD17B10ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL4829029 | 0.76 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2MAPTGAACYP3A4 | |
| SCHEMBL4825681 | 0.76 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2MAPTGAATDP1 | |
| SCHEMBL4825771 | 0.75 | ALOX15 (0.39) | ALDH1A1SMN1; SMN2NPSR1GAAPOLB | |
| SCHEMBL4831211 | 0.74 | ALDH1A1 (0.43) | LMNAHSD17B10ALDH1A1MAPTTDP1 | |
| SCHEMBL4829270 | 0.74 | ALDH1A1 (0.43) | ABCB1ALDH1A1SMN1; SMN2MAPTPOLB | |
| SCHEMBL4833165 | 0.74 | ALDH1A1 (0.38) | HSD17B10ALDH1A1MAOBGAAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080287466-A1 | 4-AMINO-2,3-DISUBSTITUTED THIENO [2,3,D]PYRIMIDINES AND PHARMACEUTICAL COMPOSITIONS THEREOF | ADAMS JERRY LEROY | 2008-11-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080287466-A1 | 4-AMINO-2,3-DISUBSTITUTED THIENO [2,3,D]PYRIMIDINES AND PHARMACEUTICAL COMPOSITIONS THEREOF | TIE1, TEK, KDR | ABCB1 1433/4885LMNA 4131/4885HSD17B10 3395/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.