Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB2 | Q9UBS0 | 1/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 5/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 5/20 | 0.38 |
| ▸ | ADRB3 | P13945 | 4/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MLYCD | O95822 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | FDPS | P14324 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.33 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12868678 | 0.90 | RPS6KB2 (0.41) | RPS6KB2ADRB2ADRB1ADRB3HPGD | |
| SCHEMBL10289763 | 0.78 | RPS6KB2 (0.44) | RPS6KB2HPGDTSHRKDM4ECYP11B1 | |
| SCHEMBL15825442 | 0.78 | RPS6KB2 (0.44) | RPS6KB2HPGDTSHRKDM4ECYP11B1 | |
| SCHEMBL4594749 | 0.77 | SMN1; SMN2 (0.55) | RPS6KB2HPGDTSHRKDM4EALDH1A1 | |
| SCHEMBL4008532 | 0.77 | RPS6KB2 (0.43) | RPS6KB2HPGDTSHRKDM4ECYP11B1 | |
| SCHEMBL5129657 | 0.76 | CYP11B1 (0.43) | RPS6KB2ADRB2ADRB1CYP11B1CYP11B2 | |
| Bromide SCHEMBL15825194 | 0.76 | SMN1; SMN2 (0.54) | RPS6KB2HPGDTSHRKDM4EALDH1A1 | |
| SCHEMBL13091417 | 0.75 | RPS6KB2 (0.44) | RPS6KB2HPGDMLYCDTSHRKDM4E | |
| SCHEMBL15820082 | 0.75 | RPS6KB2 (0.41) | RPS6KB2HPGDTSHRKDM4EFDPS | |
| SCHEMBL18574128 | 0.74 | ALDH1A1 (0.44) | TSHRALDH1A1LMNAMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080108675-A1 | THIAZOLE SULFONAMIDE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | PFIZER INC. | 2008-05-08 | — | — | US | disclosed |
| US-7309709-B2 | Thiazole sulfonamide compounds for the treatment of neurodegenerative disorders | PFIZER INC. (US) | 2007-12-18 | — | — | US | disclosed |
| WO-2005097114-A2 | THIAZOLE SULFONAMIDE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | PFIZER PRODUCTS INC. (US) | 2005-10-20 | — | — | WO | disclosed |
| US-20050222223-A1 | Thiazole sulfonamide compounds for the treatment of neurodegenerative disorders | PFIZER INC. | 2005-10-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050222223-A1 | Thiazole sulfonamide compounds for the treatment of neurodegenerative disorders | APP, PSEN1, PSEN2 | RPS6KB2 2281/4885ADRB2 2550/4885ADRB1 1419/4885 |
| US-20080108675-A1 | THIAZOLE SULFONAMIDE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | APP, PSEN1, PSEN2 | RPS6KB2 2281/4885ADRB2 2550/4885ADRB1 1419/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.