Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.39 |
| ▸ | VDR | P11473 | 1/20 | 0.38 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12868678 | 0.80 | RPS6KB2 (0.41) | ALDH1A1ADRB2ADRB1MAPTTP53 | |
| SCHEMBL5128640 | 0.76 | RPS6KB2 (0.40) | CYP11B1CYP11B2ALDH1A1ADRB2ADRB1 | |
| SCHEMBL6180184 | 0.69 | CTSK (0.49) | — | |
| SCHEMBL1445627 | 0.69 | F2RL1 (0.73) | CYP11B1CYP11B2ALDH1A1FFAR1MAPT | |
| SCHEMBL10220130 | 0.69 | POLB (0.64) | ALDH1A1ABL1SIRT2POLBMEN1 | |
| SCHEMBL4008532 | 0.69 | RPS6KB2 (0.43) | CYP11B1CYP11B2ALDH1A1FFAR1GAA | |
| SCHEMBL15825442 | 0.67 | RPS6KB2 (0.44) | CYP11B1CYP11B2ALDH1A1GAAMAPT | |
| SCHEMBL10289763 | 0.67 | RPS6KB2 (0.44) | CYP11B1CYP11B2ALDH1A1FFAR1GAA | |
| SCHEMBL4594749 | 0.66 | SMN1; SMN2 (0.55) | ALDH1A1MAPTPOLBTDP1L3MBTL1 | |
| SCHEMBL18574128 | 0.66 | ALDH1A1 (0.44) | ALDH1A1MAPTTP53MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080108675-A1 | THIAZOLE SULFONAMIDE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | PFIZER INC. | 2008-05-08 | — | — | US | disclosed |
| US-7309709-B2 | Thiazole sulfonamide compounds for the treatment of neurodegenerative disorders | PFIZER INC. (US) | 2007-12-18 | — | — | US | disclosed |
| US-20050222223-A1 | Thiazole sulfonamide compounds for the treatment of neurodegenerative disorders | PFIZER INC. | 2005-10-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050222223-A1 | Thiazole sulfonamide compounds for the treatment of neurodegenerative disorders | APP, PSEN1, PSEN2 | CYP11B1 2180/4885CYP11B2 2562/4885ALDH1A1 1228/4885 |
| US-20080108675-A1 | THIAZOLE SULFONAMIDE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | APP, PSEN1, PSEN2 | CYP11B1 2180/4885CYP11B2 2562/4885ALDH1A1 1228/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.