Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.31 |
| ▸ | HTR2C | P28335 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4319758 | 1.00 | LMNA (0.41) | LMNAMAOASLC6A2HSD11B1HTR2C | |
| SCHEMBL28957039 | 0.84 | HTR2C (0.47) | HSD11B1HTR2C | |
| SCHEMBL29698141 | 0.84 | HTR2C (0.47) | HSD11B1HTR2C | |
| SCHEMBL28957041 | 0.84 | HTR2C (0.47) | HSD11B1HTR2C | |
| SCHEMBL14521456 | 0.75 | MAOB (0.42) | MAOAHSD11B1 | |
| SCHEMBL1705219 | 0.75 | MAOB (0.42) | MAOAHSD11B1 | |
| SCHEMBL13950143 | 0.75 | MAOB (0.42) | MAOAHSD11B1 | |
| SCHEMBL28730831 | 0.73 | CA1 (0.42) | LMNAMAOASLC6A2HSD11B1 | |
| SCHEMBL28730830 | 0.73 | CA1 (0.42) | LMNAMAOASLC6A2HSD11B1 | |
| SCHEMBL3650411 | 0.72 | DDB1 (0.41) | LMNASLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1973546-A2 | CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS | Merck & Co., Inc. (US) | 2008-10-01 | — | — | EP | disclosed |
| WO-2007081570-A2 | CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS | MERCK & CO., INC. (US) | 2007-07-19 | — | — | WO | disclosed |