Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 11/20 | 0.61 |
| ▸ | AR | P10275 | 1/20 | 0.45 |
| ▸ | PTPN2 | P17706 | 8/20 | 0.36 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.31 |
| ▸ | HTR3B | O95264 | 1/20 | 0.31 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.31 |
| ▸ | HTR3A | P46098 | 1/20 | 0.31 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.31 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5121857 | 0.81 | PTPN1 (0.40) | PTPN1PTPN2 | |
| SCHEMBL6689304 | 0.78 | PTPN1 (0.81) | PTPN1PTPN2SLC40A1 | |
| SCHEMBL1732116 | 0.77 | PTPN1 (1.00) | PTPN1PTPN2SLC40A1 | |
| SCHEMBL1731402 | 0.76 | PTPN1 (0.96) | PTPN1PTPN2SLC40A1 | |
| SCHEMBL6672718 | 0.71 | PTPN1 (0.59) | PTPN1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL5127535 | 0.71 | AR (0.40) | PTPN1ARGABRA1GABRG2GABRB3 | |
| SCHEMBL5116344 | 0.71 | PTPN1 (0.51) | PTPN1PTPN2 | |
| SCHEMBL643464 | 0.70 | PTPN1 (0.66) | PTPN1PTPN2 | |
| SCHEMBL3572033 | 0.70 | PTPN1 (0.66) | PTPN1PTPN2SLC40A1HTR3EHTR3B | |
| SCHEMBL1688153 | 0.70 | PTPN1 (0.66) | PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080004325-A1 | PTP1B inhibitors | WYETH (US) | 2008-01-03 | — | — | US | claimed |
| US-20080004325-A1 | PTP1B inhibitors | WYETH (US) | 2008-01-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080004325-A1 | PTP1B inhibitors | PTPA, PTPRJ, PTPRR | PTPN1 18/4885AR 3130/4885PTPN2 14/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.