Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 5/20 | 0.59 |
| ▸ | PGR | P06401 | 3/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TDP2 | O95551 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.38 |
| ▸ | HTR3B | O95264 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6690418 | 0.87 | PTPN1 (0.73) | PTPN1HTTTP53CYP1A2CYP3A4 | |
| SCHEMBL2927665 | 0.81 | PTPN1 (0.67) | PTPN1PGRALOX5TDP2PARP10 | |
| SCHEMBL643464 | 0.77 | PTPN1 (0.66) | PTPN1MEN1KMT2AMAPT | |
| SCHEMBL1731203 | 0.77 | PTPN1 (0.66) | PTPN1MGLL | |
| SCHEMBL1688153 | 0.77 | PTPN1 (0.66) | PTPN1ALOX5MEN1KMT2AGAA | |
| SCHEMBL6684475 | 0.77 | PTPN1 (0.66) | PTPN1ALOX5MEN1KMT2AGAA | |
| SCHEMBL1732116 | 0.75 | PTPN1 (1.00) | PTPN1ALOX5MEN1KMT2AGAA | |
| SCHEMBL1731402 | 0.74 | PTPN1 (0.96) | PTPN1ALOX5MEN1KMT2AGAA | |
| SCHEMBL1732288 | 0.73 | PTPN1 (0.65) | PTPN1MEN1KMT2AGAAMAPT | |
| SCHEMBL15158748 | 0.73 | PTPN1 (0.60) | PTPN1ALOX5MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004041799-A1 | 5- (SUBSTITUTED PHENYL) -THIADIAZOLIDINE-3-ONES AND THEIR USE AS PTP1B | ASTRAZENECA AB (SE) | 2004-05-21 | — | — | WO | disclosed |