Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | FDPS | P14324 | 1/20 | 0.42 |
| ▸ | MOK | Q9UQ07 | 3/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | PPIA | P62937 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | GHSR | Q92847 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3340079 | 0.94 | JAK2 (0.47) | JAK2FDPSCYP11B1CYP11B2TSHR | |
| SCHEMBL3339894 | 0.92 | BRAF (0.47) | FDPSMOKMEN1KMT2AKDM4E | |
| SCHEMBL5129183 | 0.90 | GHSR (0.49) | JAK2FDPSMOKCYP11B1CYP11B2 | |
| SCHEMBL3336607 | 0.87 | BRAF (0.46) | FDPSMOKTDP1MEN1KMT2A | |
| SCHEMBL3334534 | 0.85 | DHODH (0.48) | KDM4EALDH1A1HPGDAPPACHE | |
| SCHEMBL3331750 | 0.84 | TTK (0.48) | FDPSMOKTDP1MEN1KMT2A | |
| SCHEMBL3341282 | 0.83 | GHSR (0.54) | JAK2FDPSCYP11B1CYP11B2TSHR | |
| SCHEMBL3335706 | 0.83 | NAMPT (0.42) | KDM4EBRAFALDH1A1MAPTHPGD | |
| SCHEMBL3336288 | 0.83 | MOK (0.47) | FDPSMOKMEN1KMT2AKDM4E | |
| SCHEMBL3338586 | 0.82 | ACHE (0.54) | TSHRTDP1MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008009077-A2 | 4,6-DL- AND 2,4,6-TRISUBSTITUTED QUINAZOLINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS USEFUL FOR TREATING VIRAL INFECTIONS | GILEAD SCIENCES, INC. (US) | 2008-01-24 | — | — | WO | claimed |