Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.59 |
| ▸ | USP2 | O75604 | 6/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | GRM5 | P41594 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 8/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5118589 | 0.94 | ALDH1A1 (0.54) | ALDH1A1USP2MAPTTSHRGRM5 | |
| SCHEMBL5118736 | 0.84 | PTPN11 (0.46) | ALDH1A1USP2MAPTTSHRGRM5 | |
| SCHEMBL5129480 | 0.84 | GRM5 (0.48) | ALDH1A1USP2MAPTTSHRGRM5 | |
| SCHEMBL5116452 | 0.83 | GRM5 (0.44) | ALDH1A1USP2MAPTTSHRGRM5 | |
| SCHEMBL5126023 | 0.83 | PTPN11 (0.45) | ALDH1A1MAPTTSHRGRM5SMN1; SMN2 | |
| SCHEMBL5129768 | 0.82 | GRM5 (0.54) | ALDH1A1GRM5CHRM2 | |
| SCHEMBL5115717 | 0.82 | ALDH1A1 (0.51) | ALDH1A1MAPTTSHRGRM5CYP3A4 | |
| SCHEMBL5119789 | 0.81 | MEN1 (0.48) | ALDH1A1GRM5SMN1; SMN2CHRM2LMNA | |
| SCHEMBL5119724 | 0.81 | MAPT (0.54) | ALDH1A1MAPTGAASMN1; SMN2NPC1 | |
| SCHEMBL5115507 | 0.80 | SCN5A (0.54) | ALDH1A1MAPTGRM5SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080269250-A1 | Pyrrolidine and Piperidine Acetylene Derivatives for Use as Mglur5 Antagonists | NOVARTIS AG (CH) | 2008-10-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080269250-A1 | Pyrrolidine and Piperidine Acetylene Derivatives for Use as Mglur5 Antagonists | GRM5, GRIK5, GRM1 | ALDH1A1 908/4885USP2 3760/4885MAPT 1486/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.