Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 8/20 | 0.54 |
| ▸ | MGLL | Q99685 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.49 |
| ▸ | ATXN2 | Q99700 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA7 | P43166 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5124023 | 0.92 | SMN1; SMN2 (0.58) | GRM5MGLLALDH1A1HSD11B1 | |
| SCHEMBL5124060 | 0.90 | ENPP2 (0.48) | GRM5MGLLENPP2ATXN2ALDH1A1 | |
| SCHEMBL5125577 | 0.89 | PKM (0.47) | GRM5PKMENPP2ATXN2ALDH1A1 | |
| SCHEMBL5115603 | 0.89 | MGLL (0.51) | GRM5MGLLENPP2ATXN2ALDH1A1 | |
| SCHEMBL5124212 | 0.89 | MAPT (0.48) | GRM5ENPP2ATXN2HSD11B1 | |
| SCHEMBL5129080 | 0.89 | MGLL (0.53) | GRM5MGLLENPP2ATXN2ALDH1A1 | |
| SCHEMBL5120360 | 0.88 | HPGD (0.48) | GRM5ENPP2ATXN2ALDH1A1CHRM2 | |
| SCHEMBL5130061 | 0.88 | HSD11B1 (0.53) | GRM5MGLLENPP2ATXN2ALDH1A1 | |
| SCHEMBL5115972 | 0.88 | PKM (0.64) | GRM5PKMENPP2ATXN2ALDH1A1 | |
| SCHEMBL5115539 | 0.87 | SMN1; SMN2 (0.50) | GRM5MGLLENPP2ATXN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080269250-A1 | Pyrrolidine and Piperidine Acetylene Derivatives for Use as Mglur5 Antagonists | NOVARTIS AG (CH) | 2008-10-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080269250-A1 | Pyrrolidine and Piperidine Acetylene Derivatives for Use as Mglur5 Antagonists | GRM5, GRIK5, GRM1 | GRM5 1/4885MGLL 3523/4885PKM 946/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.