Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRIM58 | Q8NG06 | 1/20 | 0.41 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.40 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.37 |
| ▸ | AKT2 | P31751 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5129519 | 0.89 | MGLL (0.40) | MGLLPOLBHPGDADORA2AADORA1 | |
| SCHEMBL3340183 | 0.87 | TRIM58 (0.50) | TRIM58CNR2SCN9AAKT1AKT2 | |
| SCHEMBL3336761 | 0.84 | HPGD (0.51) | MGLLL3MBTL1HPGD | |
| SCHEMBL3335650 | 0.83 | HPGD (0.50) | MGLLL3MBTL1HPGD | |
| SCHEMBL3335317 | 0.82 | MAP4K4 (0.48) | — | |
| SCHEMBL3336243 | 0.81 | TRIM58 (0.48) | TRIM58AKT1AKT2 | |
| SCHEMBL3338030 | 0.78 | PLK1 (0.46) | — | |
| SCHEMBL5127579 | 0.78 | HPGD (0.44) | MGLLL3MBTL1HPGD | |
| SCHEMBL3336878 | 0.76 | TRIM58 (0.46) | TRIM58CNR2PDE4D | |
| SCHEMBL3333969 | 0.76 | HPGD (0.43) | MGLLPOLBL3MBTL1HPGDADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008009077-A2 | 4,6-DL- AND 2,4,6-TRISUBSTITUTED QUINAZOLINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS USEFUL FOR TREATING VIRAL INFECTIONS | GILEAD SCIENCES, INC. (US) | 2008-01-24 | — | — | WO | disclosed |