Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRIM58 | Q8NG06 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 2/20 | 0.37 |
| ▸ | NPR1 | P16066 | 1/20 | 0.35 |
| ▸ | TTK | P33981 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 2/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | TDO2 | P48775 | 1/20 | 0.34 |
| ▸ | CTPS1 | P17812 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3337025 | 0.86 | TRIM58 (0.56) | TRIM58HTR2AKCNH2HTR4NPR1 | |
| SCHEMBL5179372 | 0.85 | TRIM58 (0.41) | TRIM58HTR2AKCNH2HTR4SYK | |
| SCHEMBL3335653 | 0.85 | SYK (0.45) | TRIM58SYKTTKMAPK8BRAF | |
| SCHEMBL3333273 | 0.82 | KMT2A (0.47) | SYKBRAFPIK3CAMEN1LMNA | |
| SCHEMBL3331750 | 0.81 | TTK (0.48) | TTKMAPK8BRAFMEN1LMNA | |
| SCHEMBL3333859 | 0.80 | TRIM58 (0.55) | TRIM58HTR2AKCNH2HTR4NPR1 | |
| SCHEMBL3341530 | 0.78 | PIK3CA (0.44) | TRIM58SYKBRAFPIK3CAMEN1 | |
| SCHEMBL3337337 | 0.76 | TRIM58 (0.48) | TRIM58HTR2AKCNH2HTR4BRAF | |
| SCHEMBL5131263 | 0.76 | KCNH2 (0.44) | TRIM58HTR2AKCNH2HTR4CNR2 | |
| SCHEMBL3340067 | 0.75 | MAPK10 (0.43) | SYKBRAFPIK3CAMAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008009077-A2 | 4,6-DL- AND 2,4,6-TRISUBSTITUTED QUINAZOLINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS USEFUL FOR TREATING VIRAL INFECTIONS | GILEAD SCIENCES, INC. (US) | 2008-01-24 | — | — | WO | disclosed |