Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.44 |
| ▸ | HTR4 | Q13639 | 3/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.41 |
| ▸ | MOK | Q9UQ07 | 6/20 | 0.41 |
| ▸ | TRIM58 | Q8NG06 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3336361 | 0.87 | MOK (0.51) | MOKPIK3CAJAK2MTORGRM4 | |
| SCHEMBL5146071 | 0.86 | MAP3K11 (0.45) | KCNH2HTR4HTR2ATRIM58PIK3CA | |
| SCHEMBL3337025 | 0.82 | TRIM58 (0.56) | KCNH2HTR4HTR2ATRIM58 | |
| SCHEMBL3334893 | 0.80 | MAPK14 (0.49) | KCNH2HTR2AMOKPIK3CAGRM4 | |
| SCHEMBL3336288 | 0.80 | MOK (0.47) | MOKGRM4ATM | |
| SCHEMBL3339979 | 0.79 | KIT (0.48) | PIK3CA | |
| SCHEMBL3339873 | 0.79 | MOK (0.50) | MOKPIK3CAJAK2MTORGRM4 | |
| SCHEMBL5127444 | 0.79 | AVPR1B (0.39) | KCNH2HTR4HTR2AMOKTRIM58 | |
| SCHEMBL3331750 | 0.77 | TTK (0.48) | MOK | |
| SCHEMBL5131738 | 0.76 | PDGFRB (0.45) | PDGFRBMOKPIK3CAJAK2GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008009077-A2 | 4,6-DL- AND 2,4,6-TRISUBSTITUTED QUINAZOLINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS USEFUL FOR TREATING VIRAL INFECTIONS | GILEAD SCIENCES, INC. (US) | 2008-01-24 | — | — | WO | claimed |