Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20015178 | 0.84 | ITGB3 (0.38) | — | |
| SCHEMBL2184756 | 0.82 | PTPN7 (0.45) | KMT2A | |
| SCHEMBL20014841 | 0.82 | ITGB3 (0.35) | — | |
| SCHEMBL20014376 | 0.80 | LMNA (0.46) | NPC1RAB9AKMT2APOLB | |
| SCHEMBL20014654 | 0.80 | HTT (0.46) | — | |
| SCHEMBL20014699 | 0.79 | ITGB3 (0.35) | — | |
| SCHEMBL20014364 | 0.77 | KDM4E (0.37) | MEN1KMT2AALDH1A1 | |
| SCHEMBL23341013 | 0.77 | ITGB3 (0.36) | — | |
| SCHEMBL20015188 | 0.74 | ITGB3 (0.37) | — | |
| SCHEMBL5132211 | 0.73 | AKR1B1 (0.45) | RAB9AMEN1KMT2APOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1950212-B1 | POLYCYCLIC CARBAMOYLPYRIDONE DERIVATIVE HAVING INHIBITORY ACTIVITY ON HIV INTEGRASE | SHIONOGI & CO (JP) | 2016-02-24 | — | — | EP | disclosed |
| EP-1950212-A1 | POLYCYCLIC CARBAMOYLPYRIDONE DERIVATIVE HAVING INHIBITORY ACTIVITY ON HIV INTEGRASE | Shionogi Co., Ltd. (JP) | 2008-07-30 | — | — | EP | disclosed |