Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 6/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL312089 | 0.83 | MAPT (0.61) | MAPTALDH1A1KMT2ATSHRMEN1 | |
| SCHEMBL5132403 | 0.80 | MAPT (0.54) | MAPTALDH1A1KMT2ATSHRMEN1 | |
| SCHEMBL5132401 | 0.79 | MAPT (0.56) | MAPTALDH1A1KMT2ATSHRMEN1 | |
| SCHEMBL312494 | 0.77 | KDM4E (0.54) | MAPTALDH1A1KMT2ATSHRMEN1 | |
| SCHEMBL312526 | 0.72 | KDM4E (0.70) | MAPTALDH1A1KMT2ATSHRMEN1 | |
| SCHEMBL312268 | 0.71 | LMNA (0.61) | MAPTALDH1A1KMT2ATSHRMEN1 | |
| SCHEMBL30576174 | 0.71 | KMT2A (0.59) | MAPTALDH1A1KMT2ATSHRMEN1 | |
| SCHEMBL313733 | 0.71 | KDM4E (0.57) | MAPTALDH1A1KMT2ATSHRMEN1 | |
| SCHEMBL4211561 | 0.71 | KMT2A (0.73) | MAPTALDH1A1KMT2ATSHRMEN1 | |
| SCHEMBL312488 | 0.71 | ALDH1A1 (0.59) | MAPTALDH1A1KMT2ATSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761541-B1 | PYRRAZOLO-PYRIMIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2008-01-09 | — | — | EP | disclosed |