Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVRL1 | P37023 | 7/20 | 0.51 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.43 |
| ▸ | CFTR | P13569 | 6/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 5/20 | 0.36 |
| ▸ | FEN1 | P39748 | 5/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14700077 | 0.83 | ACVRL1 (0.49) | ACVRL1RIPK1CFTR | |
| SCHEMBL5146643 | 0.81 | ACVRL1 (0.53) | ACVRL1RIPK1 | |
| SCHEMBL842395 | 0.81 | ACVRL1 (0.41) | ACVRL1RIPK1ALOX5APFEN1 | |
| SCHEMBL58182 | 0.80 | FLT3 (0.54) | ACVRL1RIPK1 | |
| SCHEMBL5139994 | 0.77 | ACVRL1 (0.46) | ACVRL1ALOX5APFEN1 | |
| SCHEMBL5141128 | 0.75 | FGFR1 (0.51) | RIPK1 | |
| SCHEMBL5132591 | 0.74 | ACVRL1 (0.52) | ACVRL1RIPK1ALOX5APFEN1 | |
| SCHEMBL2999462 | 0.73 | KCNH2 (0.39) | ACVRL1RIPK1ALOX5APFEN1 | |
| SCHEMBL5108845 | 0.73 | ACVRL1 (0.58) | ACVRL1ALOX5APFEN1 | |
| SCHEMBL5031488 | 0.73 | ACVRL1 (0.48) | ACVRL1RIPK1CFTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957485-A2 | SUBSTITUTED 4-AMINO-PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS | Bayer Healthcare, LLC (US) | 2008-08-20 | — | — | EP | disclosed |
| WO-2007064931-A2 | SUBSTITUTED 4-AMINO-PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS | BAYER HEALTHCARE LLC (US) | 2007-06-07 | — | — | WO | disclosed |