Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVRL1 | P37023 | 11/20 | 0.53 |
| ▸ | TYRO3 | Q06418 | 4/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | PLAT | P00750 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5139204 | 0.91 | ACVRL1 (0.48) | ACVRL1TYRO3PIK3CD | |
| SCHEMBL5116564 | 0.90 | ACVRL1 (0.51) | ACVRL1TYRO3BTK | |
| SCHEMBL59782 | 0.81 | ACVRL1 (0.53) | ACVRL1TYRO3RIPK1BTK | |
| SCHEMBL5132542 | 0.81 | ACVRL1 (0.51) | ACVRL1RIPK1 | |
| SCHEMBL83034 | 0.79 | TYRO3 (0.49) | ACVRL1TYRO3PIK3CD | |
| SCHEMBL5146988 | 0.79 | ACVRL1 (0.44) | ACVRL1TYRO3 | |
| SCHEMBL58550 | 0.78 | TYRO3 (0.58) | ACVRL1TYRO3RIPK1BTK | |
| SCHEMBL59129 | 0.78 | ACVRL1 (0.51) | ACVRL1TYRO3RIPK1BTK | |
| SCHEMBL842395 | 0.77 | ACVRL1 (0.41) | ACVRL1PIK3CDRIPK1 | |
| SCHEMBL59118 | 0.77 | ACVRL1 (0.57) | ACVRL1TYRO3RIPK1BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957485-A2 | SUBSTITUTED 4-AMINO-PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS | Bayer Healthcare, LLC (US) | 2008-08-20 | — | — | EP | claimed |
| WO-2007064931-A2 | SUBSTITUTED 4-AMINO-PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS | BAYER HEALTHCARE LLC (US) | 2007-06-07 | — | — | WO | claimed |