Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL512774 | 0.91 | GRM5 (0.45) | GRM5MAPTCYP3A4POLBTP53 | |
| SCHEMBL512191 | 0.89 | GRM5 (0.44) | GRM5NPC1RAB9ACYP3A4POLB | |
| SCHEMBL513747 | 0.88 | GRM5 (0.42) | GRM5CYP3A4POLBTP53GAA | |
| SCHEMBL512815 | 0.88 | GRM5 (0.48) | GRM5MAPTCYP3A4POLBTP53 | |
| SCHEMBL512323 | 0.88 | GRM5 (0.48) | GRM5MAPTCYP3A4POLBTP53 | |
| SCHEMBL512324 | 0.88 | GRM5 (0.48) | GRM5MAPTCYP3A4POLBTP53 | |
| SCHEMBL512792 | 0.86 | RXFP1 (0.52) | GRM5NPC1RAB9AMAPTCYP3A4 | |
| SCHEMBL513137 | 0.86 | GRM5 (0.47) | GRM5MAPTCYP3A4POLBTP53 | |
| SCHEMBL513138 | 0.86 | GRM5 (0.47) | GRM5MAPTCYP3A4POLBTP53 | |
| SCHEMBL513633 | 0.86 | GRM5 (0.47) | GRM5MAPTCYP3A4POLBTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120028931-A1 | HETEROCYCLIC M-GLU5 ANTAGONISTS | RECORDATI IRELAND LIMITED (IE) | 2012-02-02 | — | — | US | claimed |
| US-20120028931-A1 | HETEROCYCLIC M-GLU5 ANTAGONISTS | RECORDATI IRELAND LIMITED (IE) | 2012-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028931-A1 | HETEROCYCLIC M-GLU5 ANTAGONISTS | OPRM1, GRM5, OPRD1 | GRM5 2/4885NPC1 4017/4885RAB9A 2058/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.