Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVRL1 | P37023 | 19/20 | 0.43 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
| ▸ | MERTK | Q12866 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5031488 | 0.86 | ACVRL1 (0.48) | ACVRL1AXLMERTK | |
| SCHEMBL58728 | 0.78 | ACVRL1 (0.44) | ACVRL1AXLMERTK | |
| SCHEMBL5132559 | 0.76 | ACVRL1 (0.51) | ACVRL1MERTK | |
| SCHEMBL5133496 | 0.72 | ACVRL1 (0.48) | ACVRL1AXLMERTK | |
| SCHEMBL59573 | 0.71 | ACVRL1 (0.65) | ACVRL1 | |
| SCHEMBL862462 | 0.70 | AXL (0.41) | ACVRL1AXLMERTK | |
| SCHEMBL27747164 | 0.69 | ACVRL1 (0.47) | ACVRL1AXLMERTK | |
| SCHEMBL10278402 | 0.69 | ACVRL1 (0.44) | ACVRL1AXLMERTK | |
| SCHEMBL59064 | 0.69 | AXL (0.40) | ACVRL1AXLMERTK | |
| SCHEMBL22676013 | 0.69 | ACVRL1 (0.50) | ACVRL1AXLMERTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957485-A2 | SUBSTITUTED 4-AMINO-PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS | Bayer Healthcare, LLC (US) | 2008-08-20 | — | — | EP | disclosed |
| WO-2007064931-A2 | SUBSTITUTED 4-AMINO-PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS | BAYER HEALTHCARE LLC (US) | 2007-06-07 | — | — | WO | disclosed |