Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVRL1 | P37023 | 9/20 | 0.48 |
| ▸ | RET | P07949 | 4/20 | 0.40 |
| ▸ | KDR | P35968 | 3/20 | 0.40 |
| ▸ | MERTK | Q12866 | 3/20 | 0.36 |
| ▸ | AXL | P30530 | 2/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5031488 | 0.87 | ACVRL1 (0.48) | ACVRL1RETKDRMERTKAXL | |
| SCHEMBL59041 | 0.78 | NTRK1 (0.49) | ACVRL1RETKDRMERTKAXL | |
| SCHEMBL5132640 | 0.72 | ACVRL1 (0.43) | ACVRL1MERTKAXL | |
| SCHEMBL5132542 | 0.68 | ACVRL1 (0.51) | ACVRL1 | |
| SCHEMBL16011363 | 0.67 | ACVRL1 (0.55) | ACVRL1RETKDRNTRK1NTRK2 | |
| SCHEMBL57761 | 0.67 | ACVRL1 (0.48) | ACVRL1KDRMERTKAXLNTRK1 | |
| SCHEMBL59021 | 0.64 | KDR (0.44) | ACVRL1RETKDRMERTKAXL | |
| SCHEMBL64689 | 0.63 | ACVRL1 (0.55) | ACVRL1RETKDRNTRK1NTRK2 | |
| SCHEMBL58182 | 0.60 | FLT3 (0.54) | ACVRL1RETKDRAXLNTRK1 | |
| SCHEMBL60270 | 0.60 | ACVRL1 (0.50) | ACVRL1MERTKAXLPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957485-A2 | SUBSTITUTED 4-AMINO-PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS | Bayer Healthcare, LLC (US) | 2008-08-20 | — | — | EP | disclosed |
| WO-2007064931-A2 | SUBSTITUTED 4-AMINO-PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS | BAYER HEALTHCARE LLC (US) | 2007-06-07 | — | — | WO | disclosed |