Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 6/20 | 0.53 |
| ▸ | CHRNA4 | P43681 | 6/20 | 0.53 |
| ▸ | CHRNA7 | P36544 | 5/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2212532 | 0.84 | CHRNB2 (0.50) | CHRNB2CHRNA4CHRNA7MEN1CYP2D6 | |
| SCHEMBL5848952 | 0.84 | CHRNB2 (0.50) | CHRNB2CHRNA4CHRNA7MEN1CYP2D6 | |
| SCHEMBL2212533 | 0.84 | CHRNB2 (0.50) | CHRNB2CHRNA4CHRNA7MEN1CYP2D6 | |
| SCHEMBL5848946 | 0.84 | CHRNB2 (0.50) | CHRNB2CHRNA4CHRNA7MEN1CYP2D6 | |
| SCHEMBL27335607 | 0.79 | KDM4E (0.40) | CYP2D6CYP2C19POLBCYP1A2RAB9A | |
| SCHEMBL5849102 | 0.75 | CHRNB2 (0.50) | CHRNB2CHRNA4CHRNA7MEN1CYP2D6 | |
| SCHEMBL5849098 | 0.75 | CHRNB2 (0.50) | CHRNB2CHRNA4CHRNA7MEN1CYP2D6 | |
| SCHEMBL9534693 | 0.74 | CYP11B2 (0.47) | CHRNB2CHRNA4CHRNA7MEN1KMT2A | |
| SCHEMBL6002481 | 0.74 | POLB (0.44) | POLBALDH1A1 | |
| SCHEMBL8482013 | 0.73 | CHRNB2 (0.43) | CHRNB2CHRNA4CHRNA7SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8293750-B2 | Pyrazines as delta opioid receptor modulators | JANSSEN PHARMACEUTICA NV (BE) | 2012-10-23 | — | — | US | disclosed |
| US-8183371-B2 | Pyrazines as delta opioid receptor modulators | JANSSEN PHARMACEUTICA NV (BE) | 2012-05-22 | — | — | US | disclosed |