Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.40 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 4/20 | 0.36 |
| ▸ | RXRA | P19793 | 3/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL397497 | 0.84 | BRD4 (0.41) | BRD4PAX8NR1H3RXRANR1H2 | |
| SCHEMBL27650497 | 0.81 | ESR1 (0.41) | BRD4PAX8NR1H3RXRANR1H2 | |
| SCHEMBL8018111 | 0.78 | PAX8 (0.55) | BRD4PAX8NR1H3RXRANR1H2 | |
| SCHEMBL16197281 | 0.77 | PAX8 (0.50) | BRD4PAX8NR1H3RXRANR1H2 | |
| SCHEMBL398694 | 0.77 | BRD4 (0.38) | BRD4PAX8NR1H3RXRANR1H2 | |
| SCHEMBL13674398 | 0.76 | BRD4 (0.40) | BRD4PAX8NR1H3RXRANR1H2 | |
| SCHEMBL15597297 | 0.76 | PAX8 (0.44) | BRD4PAX8NR1H3RXRANR1H2 | |
| SCHEMBL4856543 | 0.76 | ALDH1A1 (0.38) | BRD4PAX8LMNAKDM4EMAPT | |
| SCHEMBL24449497 | 0.75 | BRD4 (0.49) | BRD4PAX8 | |
| SCHEMBL6492174 | 0.75 | BRD4 (0.39) | BRD4PAX8NR1H3RXRANR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1974212-A1 | COMPOUNDS USEFUL IN CFTR ASSAYS AND METHODS THEREWITH | Vertex Pharmaceuticals Incorporated (US) | 2008-10-01 | — | — | EP | disclosed |
| WO-2007075946-A1 | COMPOUNDS USEFUL IN CFTR ASSAYS AND METHODS THEREWITH | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-07-05 | — | — | WO | disclosed |