⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL100934 | 0.79 | JAK2 (0.30) | — | |
| SCHEMBL100384 | 0.79 | TPH1 (0.32) | — | |
| SCHEMBL101565 | 0.79 | — | — | |
| SCHEMBL99779 | 0.72 | TPH1 (0.31) | — | |
| SCHEMBL15413003 | 0.72 | JAK2 (0.33) | — | |
| SCHEMBL18638273 | 0.71 | TPH1 (0.31) | — | |
| SCHEMBL99696 | 0.71 | DGAT1 (0.31) | — | |
| SCHEMBL99547 | 0.70 | JAK2 (0.33) | — | |
| SCHEMBL100209 | 0.69 | JAK2 (0.37) | — | |
| SCHEMBL15412937 | 0.69 | JAK2 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966202-A1 | HETEROARYL SUBSTITUTED PYRROLOÝ2,3-B¨PYRIDINES AND PYRROLOÝ2,3-B¨PYRIMIDINES AS JANUS KINASE INHIBITORS | Incyte Corporation (US) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007070514-A1 | HETEROARYL SUBSTITUTED PYRROLO[2,3-B]PYRIDINES AND PYRROLO[2,3-B]PYRIMIDINES AS JANUS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2007-06-21 | — | — | WO | disclosed |