Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.65 |
| ▸ | NPC1 | O15118 | 6/20 | 0.65 |
| ▸ | RAB9A | P51151 | 6/20 | 0.65 |
| ▸ | MEN1 | O00255 | 5/20 | 0.65 |
| ▸ | PKM | P14618 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | BLM | P54132 | 1/20 | 0.60 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.59 |
| ▸ | CLK2 | P49760 | 2/20 | 0.59 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.59 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.59 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | THRA | P10827 | 1/20 | 0.57 |
| ▸ | MAOB | P27338 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | NOS1 | P29475 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2924973 | 0.82 | MAP4K4 (0.60) | KMT2ANPC1RAB9AMEN1MAPT | |
| SCHEMBL3378320 | 0.81 | RAB9A (0.80) | NPC1RAB9AMAPTMAP4K4CLK2 | |
| SCHEMBL29429758 | 0.81 | RAB9A (0.80) | NPC1RAB9AMAPTMAP4K4CLK2 | |
| SCHEMBL2925388 | 0.81 | MAOB (0.62) | KMT2ANPC1RAB9AMEN1MAPT | |
| Hydrochloric Acid SCHEMBL7368705 | 0.80 | RAB9A (0.78) | NPC1RAB9AMAPTMAP4K4CLK2 | |
| SCHEMBL15652669 | 0.79 | MAP4K4 (0.61) | NPC1RAB9AMAP4K4CLK2DYRK1A | |
| SCHEMBL10943066 | 0.79 | KMT2A (0.94) | KMT2ANPC1RAB9AMEN1PKM | |
| SCHEMBL14022343 | 0.78 | RAB9A (0.67) | KMT2ANPC1RAB9AMEN1MAPT | |
| SCHEMBL271133 | 0.78 | RAB9A (0.70) | KMT2ANPC1RAB9AMEN1MAPT | |
| SCHEMBL2927325 | 0.77 | MAP4K4 (0.69) | NPC1RAB9AMAPTMAP4K4CLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1987028-A2 | BENZAZOLE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE AS AURORA KINASE INHIBITORS | Transtech Pharma, Inc. (US) | 2008-11-05 | — | — | EP | disclosed |
| WO-2007095124-A2 | BENZAZOLE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE AS AURORA KINASE INHIBITORS | TRANSTECH PHARMA, INC. (US) | 2007-08-23 | — | — | WO | disclosed |