Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.80 |
| ▸ | NPC1 | O15118 | 5/20 | 0.80 |
| ▸ | JAK2 | O60674 | 1/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.77 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.77 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.76 |
| ▸ | CLK2 | P49760 | 2/20 | 0.76 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.76 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.76 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.76 |
| ▸ | HPGD | P15428 | 3/20 | 0.68 |
| ▸ | MAOB | P27338 | 5/20 | 0.64 |
| ▸ | MAPT | P10636 | 2/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | GAA | P10253 | 1/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.63 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29429758 | 1.00 | RAB9A (0.80) | RAB9ANPC1JAK2ALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7368705 | 0.99 | RAB9A (0.78) | RAB9ANPC1JAK2ALDH1A1SMN1; SMN2 | |
| SCHEMBL3380296 | 0.89 | NPC1 (1.00) | RAB9ANPC1JAK2ALDH1A1MAP4K4 | |
| SCHEMBL21688513 | 0.84 | ROCK1 (0.79) | RAB9ANPC1JAK2ALDH1A1SMN1; SMN2 | |
| SCHEMBL15652669 | 0.83 | MAP4K4 (0.61) | RAB9ANPC1JAK2ALDH1A1SMN1; SMN2 | |
| SCHEMBL1548213 | 0.83 | ALDH1A1 (0.69) | RAB9ANPC1ALDH1A1SMN1; SMN2MAP4K4 | |
| SCHEMBL30725947 | 0.83 | ALDH1A1 (0.69) | RAB9ANPC1ALDH1A1SMN1; SMN2MAP4K4 | |
| SCHEMBL7369804 | 0.83 | NPC1 (0.82) | RAB9ANPC1ALDH1A1SMN1; SMN2MAP4K4 | |
| SCHEMBL22776426 | 0.82 | RAB9A (0.75) | RAB9ANPC1JAK2ALDH1A1SMN1; SMN2 | |
| SCHEMBL28573140 | 0.82 | KDM4E (0.71) | RAB9ANPC1JAK2ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9447033-B2 | Potassium channel blockers | JAPAN TOBACCO INC. (JP) | 2016-09-20 | — | — | US | disclosed |
| US-20150259282-A1 | Potassium Channel Blockers | XENTION LIMITED (GB) | 2015-09-17 | — | — | US | disclosed |
| US-9073834-B2 | Potassium channel blockers | XENTION LIMITED (GB) | 2015-07-07 | — | — | US | disclosed |
| US-20140221337-A1 | Potassium Channel Blockers | XENTION LIMITED (GB) | 2014-08-07 | — | — | US | disclosed |
| US-8673901-B2 | Potassium channel blockers | XENTION LIMITED (GB) | 2014-03-18 | — | — | US | disclosed |
| US-20100087428-A1 | Novel Potassium Channel Blockers | XENTION LIMITED (GB) | 2010-04-08 | — | — | US | disclosed |
| EP-1745038-A1 | FUSED HETEROARYL DERIVATIVES FOR USE AS P38 KINASE INHIBITORS IN THE TREATMENT OF I.A. RHEUMATOID ARTHRITIS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-01-24 | — | — | EP | disclosed |
| WO-2005073219-A1 | FUSED HETEROARYL DERIVATIVES FOR USE AS P38 KINASE INHIBITORS IN THE TREATMENT OF I.A. RHEUMATOID ARTHRITIS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-08-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140221337-A1 | Potassium Channel Blockers | KCNJ2, KCNH2, KCNB1 | RAB9A 1923/4885NPC1 628/4885JAK2 1913/4885 |
| US-20100087428-A1 | Novel Potassium Channel Blockers | HCN4, SCN2B, KCNH2 | RAB9A 3852/4885NPC1 905/4885JAK2 2535/4885 |
| US-20150259282-A1 | Potassium Channel Blockers | KCNJ2, KCNH2, KCNB1 | RAB9A 1923/4885NPC1 628/4885JAK2 1913/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.