Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.68 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HMGCR | P04035 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | SLC13A5 | Q86YT5 | 4/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | ACLY | P53396 | 4/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL9326615 | 0.98 | ALDH1A1 (0.65) | ALDH1A1TSHRLMNAMEN1KMT2A | |
| Citric Acid SCHEMBL15847107 | 0.96 | ALDH1A1 (0.62) | ALDH1A1TSHRLMNAMEN1KMT2A | |
| Citric Acid SCHEMBL15779277 | 0.93 | ALDH1A1 (0.79) | ALDH1A1TSHRLMNAMEN1KMT2A | |
| Citric Acid SCHEMBL27647752 | 0.93 | ALDH1A1 (0.79) | ALDH1A1TSHRLMNAMEN1KMT2A | |
| Citric Acid SCHEMBL10520117 | 0.93 | ALDH1A1 (0.79) | ALDH1A1TSHRLMNAMEN1KMT2A | |
| Citric Acid SCHEMBL332489 | 0.93 | ALDH1A1 (0.79) | ALDH1A1TSHRLMNAMEN1KMT2A | |
| Citric Acid SCHEMBL73266 | 0.93 | ALDH1A1 (0.79) | ALDH1A1TSHRLMNAMEN1KMT2A | |
| Citric Acid SCHEMBL10335265 | 0.92 | ALDH1A1 (0.58) | ALDH1A1TSHRLMNAMEN1KMT2A | |
| Citric Acid SCHEMBL23012587 | 0.91 | ALDH1A1 (0.75) | ALDH1A1TSHRLMNAMEN1KMT2A | |
| Citric Acid SCHEMBL10962662 | 0.91 | ALDH1A1 (0.75) | ALDH1A1TSHRLMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107995861-A | Inhalation solution of tiotropium for atomization | 格兰马克专业公司 | 2018-05-04 | — | — | CN | disclosed |
| EP-1718276-A4 | INHALANT FORMULATION CONTAINING SULFOALKYLETHER CYCLODEXTRIN AND CORTICOSTEROID PREPARED FROM A UNIT DOSE SUSPENSION | CYDEX INC (US) | 2008-07-23 | — | — | EP | disclosed |
| EP-1718276-A2 | INHALANT FORMULATION CONTAINING SULFOALKYLETHER CYCLODEXTRIN AND CORTICOSTEROID PREPARED FROM A UNIT DOSE SUSPENSION | Cydex Inc. (US) | 2006-11-08 | — | — | EP | disclosed |
| WO-2005065651-A1 | INHALANT FORMULATION CONTAINING SULFOALKYL ETHER CYCLODEXTRIN AND CORTICOSTEROID PREPARED FROM A UNIT DOSE SUSPENSION | CYDEX, INC. (US) | 2005-07-21 | — | — | WO | disclosed |