Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.79 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | HMGCR | P04035 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | ACLY | P53396 | 3/20 | 0.39 |
| ▸ | SLC13A5 | Q86YT5 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL10520117 | 1.00 | ALDH1A1 (0.79) | ALDH1A1TSHRLMNAMEN1KMT2A | |
| Citric Acid SCHEMBL15779277 | 1.00 | ALDH1A1 (0.79) | ALDH1A1TSHRLMNAMEN1KMT2A | |
| Citric Acid SCHEMBL332489 | 1.00 | ALDH1A1 (0.79) | ALDH1A1TSHRLMNAMEN1KMT2A | |
| Citric Acid SCHEMBL27647752 | 1.00 | ALDH1A1 (0.79) | ALDH1A1TSHRLMNAMEN1KMT2A | |
| Citric Acid SCHEMBL23012587 | 0.97 | ALDH1A1 (0.75) | ALDH1A1TSHRLMNAMEN1KMT2A | |
| Citric Acid SCHEMBL10962662 | 0.97 | ALDH1A1 (0.75) | ALDH1A1TSHRLMNAMEN1KMT2A | |
| Citric Acid SCHEMBL11531681 | 0.97 | ALDH1A1 (0.75) | ALDH1A1TSHRLMNAMEN1KMT2A | |
| Citric Acid SCHEMBL6131060 | 0.97 | ALDH1A1 (0.75) | ALDH1A1TSHRLMNAMEN1KMT2A | |
| Citric Acid SCHEMBL9333028 | 0.97 | ALDH1A1 (0.75) | ALDH1A1TSHRLMNAMEN1KMT2A | |
| Citric Acid SCHEMBL15653350 | 0.97 | ALDH1A1 (0.75) | ALDH1A1TSHRLMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 6918 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4631522-A1 | IL-17A ANTIBODY FORMULATION AND USE THEREOF | Shanghai Huaota Biopharmaceutical Co., Ltd. (CN) | 2025-10-15 | — | — | EP | claimed |
| US-12351540-B2 | Process for preparing cyanoacetates | HENKEL AG & CO. KGAA (DE) | 2025-07-08 | — | — | US | claimed |
| CN-120058877-A | Competitive ELISA method for accurately and quantitatively detecting antigen of feline calicivirus | 中牧实业股份有限公司 | 2025-05-30 | — | — | CN | claimed |
| CN-120058920-A | Anti-S11 type riemerella anatipestifer monoclonal antibody, blocking ELISA antibody detection kit and application thereof | 山东省农业科学院家禽研究所（山东省无特定病原鸡研究中心） | 2025-05-30 | — | — | CN | claimed |
| CN-120064640-A | Porcine parvovirus VP2 double-antibody sandwich quantitative detection kit and application thereof | 中牧实业股份有限公司 | 2025-05-30 | — | — | CN | claimed |
| CN-119776341-A | Amino acid magnetic modified biochar immobilized laccase and preparation method and application thereof | 中国海洋大学 | 2025-04-08 | — | — | CN | claimed |
| CN-119639342-A | Red sandstone cultural relic weather-proof coating and preparation method thereof | 西南石油大学 | 2025-03-18 | — | — | CN | claimed |
| CN-119431527-A | Brucella BP26 protein ELISA antibody detection kit and application thereof | 中牧实业股份有限公司 | 2025-02-14 | — | — | CN | claimed |
| CN-119192306-A | Pseudorabies virus gD protein and preparation method and application thereof | 中牧实业股份有限公司 | 2024-12-27 | — | — | CN | claimed |
| CN-118962126-A | ELISA kit for detecting porcine reproductive and respiratory syndrome virus antigen and application thereof | 中牧实业股份有限公司 | 2024-11-15 | — | — | CN | claimed |
| EP-0181374-B1 | ISOLATION OF PROTEINS OF HTLV-III, SEROLOGICAL DETECTION OF ANTIBODIES TO HTLV-III IN SERA OF PATIENTS WITH AIDS AND PRE-AIDS CONDITIONS, AND DETECTION OF HTLV-III INFECTION BY IMMUNO-ASSAYS USING HTLV-III AND ITS PROTEINS | THE UNITED STATES OF AMERICA as represented by the Secretary UNITED STATES DEPARTMENT OF COMMERCE (US) | 1991-11-21 | — | — | EP | claimed |
| EP-0231816-B1 | PHARMACEUTICAL PREPARATIONS FOR THE STABILIZATION OF INTERFERON ALPHA | Dr. Karl Thomae GmbH (DE) | 1991-05-29 | — | — | EP | claimed |
| EP-0168506-B1 | PROCESS FOR PREPARING GAMMA GLOBULIN SUITABLE FOR INTRAVENOUS ADMINISTRATION | Armour Pharma GmbH (DE) | 1990-12-19 | — | — | EP | claimed |
| US-4835257-A | Process for preparing gamma globulin suitable for intravenous administration using peg and a citrate buffer | ARMOUR PHARMA GMBH (DE) | 1989-05-30 | — | — | US | claimed |
| EP-0125258-A4 | COMPOSITION OF MATTER FROM -I(CRYPTOSIPHONIA WOODII) USEFUL FOR THE TREATMENT OF HERPES SIMPLEX VIRUS. | PAPPO RAPHAEL (US) | 1986-11-04 | — | — | EP | claimed |
| WO-1985004903-A1 | ISOLATION OF PROTEINS OF HTLV-III, SEROLOGICAL DETECTION OF ANTIBODIES TO HTLV-III IN SERA OF PATIENTS WITH AIDS AND PRE-AIDS CONDITIONS, AND DETECTION OF HTLV-III INFECTION BY IMMUNO-ASSAYS USING HTLV-III AND ITS PROTEINS | UNITED STATES OF AMERICA, REPRESENTED BY THE UNITE (US) | 1985-11-07 | — | — | WO | claimed |
| US-4520113-A | STRIP RADIOIMMUNOASSY OR ENZYME-LINKED IMMUNOASSAY | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1985-05-28 | — | — | US | claimed |
| EP-0125258-A1 | COMPOSITION OF MATTER FROM $I(CRYPTOSIPHONIA WOODII) USEFUL FOR THE TREATMENT OF HERPES SIMPLEX VIRUS | PAPPO, Raphael (US) | 1984-11-21 | — | — | EP | claimed |
| WO-1984001712-A1 | COMPOSITION OF MATTER FROM $I(CRYPTOSIPHONIA WOODII) USEFUL FOR THE TREATMENT OF HERPES SIMPLEX VIRUS | PAPPO RAPHAEL (US) | 1984-05-10 | — | — | WO | claimed |
| US-4255517-A | ORGANIC BUFFERS, MICROCOCCUS LYSODIEKTICUS, AMNIOTIC FLUID SAMPLE, CELL LYSIS ZONE | FORD LARRY C | 1981-03-10 | — | — | US | claimed |