Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.38 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.38 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.38 |
| ▸ | FNTA | P49354 | 1/20 | 0.37 |
| ▸ | FNTB | P49356 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL489425 | 0.81 | MAPT (0.47) | MAPTALDH1A1TDP1HTTSMN1; SMN2 | |
| SCHEMBL27787299 | 0.79 | MAPT (0.46) | MAPTALDH1A1TDP1HTTSMN1; SMN2 | |
| SCHEMBL3957592 | 0.79 | MAPT (0.46) | MAPTALDH1A1TDP1HTTSMN1; SMN2 | |
| SCHEMBL28291905 | 0.79 | MAPT (0.46) | MAPTALDH1A1TDP1HTTSMN1; SMN2 | |
| SCHEMBL10982843 | 0.79 | MAPT (0.50) | MAPTALDH1A1TDP1HTTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL17710427 | 0.79 | MAPT (0.46) | MAPTALDH1A1TDP1HTTSMN1; SMN2 | |
| SCHEMBL10078834 | 0.79 | MAPT (0.46) | MAPTALDH1A1TDP1HTTSMN1; SMN2 | |
| SCHEMBL3542022 | 0.79 | MAPT (0.46) | MAPTALDH1A1TDP1HTTSMN1; SMN2 | |
| SCHEMBL7950616 | 0.79 | MAPT (0.50) | MAPTALDH1A1TDP1HTTSMN1; SMN2 | |
| SCHEMBL902381 | 0.79 | SIGMAR1 (0.50) | MAPTL3MBTL1TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1974212-A1 | COMPOUNDS USEFUL IN CFTR ASSAYS AND METHODS THEREWITH | Vertex Pharmaceuticals Incorporated (US) | 2008-10-01 | — | — | EP | disclosed |
| WO-2007075946-A1 | COMPOUNDS USEFUL IN CFTR ASSAYS AND METHODS THEREWITH | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-07-05 | — | — | WO | disclosed |